With the aim of improving productive potential of black pied cattle, preventing and treating clinical mastitis we used biopreparations developed by scientists of the Federal State Budgetary Establishment of Higher Education ‘Chuvash State Agrarian University’: Prevention-N-E and Prevention-N-B-S, as well as Mastinol, homeopathic medicinal product for treatment of mastitis. It follows from the results of our studies that the biological preparations used in the experiments did not influence the physiological condition of animals but activated cell factors of non-specific organism protection. The most obvious effect was demonstrated by Prevention-N-B-S, rather than Prevention-N-E, however this difference was insignificant (P>0.05). Prevention of mastitis in cows with Prevention-N-B-S biopreparation turned out to be more effective than with Prevention-N-E and Mastinol. Recovery of one cow of the 1st experimental group treated by Prevention-N-E took place in 4±0.08 days, which is 7±52 less than in the 3rd experimental group, where Mastinol was used. Atrophy of an udder lobe was observed in one cow in the 3rd experimental group. As a result, the issue of pathogenetic therapy of mastitis in cows is still relevant and we plan to solve it with the use of immunostimulants.

Our work provided for the study of the impact of directed reproduction of cows on the formation of highly productive healthy herds in the basic farms of the Republic of Kazakhstan. For accelerated replacement of herd and increase of number of highly productive cows in large farms for milk production one uses sexed semen at the first and the second insemination of primiparous cows obtained from highly productive mothers. The efficiency obtained from using this technique is 65-95% of individuals of the desired sex. Insemination was carried out by recto-cervical method using a tool AlphaVision frozen-thawed sexed semen divided by sex. The highest results of the fruitfulness of insemination with sexed semen in Agricultural production cooperative “Breeding Plant Almaty”, Individual entrepreneur “Karimov” and Kakpatas Kordai were obtained in the autumn-winter period and ranged from 58.1 to 65.2%, with an insemination index of 1.58-1.72. Economic efficiency when using the technology of artificial insemination of calves with sexed semen amounted to 10,040.2 tenge. When using sexed semen, an average of 92% of calves were obtained from bovine. Less insemination costs, the profit from calf production amounted to 76,109.2 tenge.

A scientific and practical substantiation of the need for the timely formation of colostral immunity in calves to create nonspecific protection of the body and adaptation of newborns to new environmental conditions is given, which is the most important problem of modern veterinary science and practice. Colostral immunity is immunity that develops in newborns due to colostral immunoglobulins during the first 24-36 hours of life. For some newborn farm animals (horses, ruminants and pigs), antibodies are transmitted to offspring only through colostrum in the early postnatal period. In order to increase the nonspecific defenses of the body of mothers cows, the formation of colostral immunity in newborn calves and the realization of the biological resource potential of the body, immunostimulants were used, developed by scientists of the Chuvash State Agrarian University: Prevention-N-B-S and Salus-PE.