Pathogenic microorganisms are causative agents for different types of serious and even lethal infectious diseases. Despite advancements in medication, bacterial and fungal infections continue to be a growing problem in health care. As more and more bacteria become resistant to antibiotics used in therapy and an increasing number of invasive fungal species become resistant to current antifungal medications, there is considerable interest in the development of new compounds with antimicrobial activity. The compounds containing a heterocyclic ring play an important role among organic compounds with biological activity used as drugs in human and veterinary medicine or as insecticides and pesticides in agriculture. Thiadiazoles belong to the classes of nitrogen–sulfur heterocycles with extensive application as structural units of biologically active molecules and as useful intermediates in medicinal chemistry. The potency of the thiadiazole nucleus is demonstrated by the drugs currently used. 1,3,4-Thiadiazoles and some of their derivatives are extensively studied because of their broad spectrum of pharmacological activities. The aim of this review was to highlight the main antimicrobial properties exhibited by derivatives possessing 2-amino-1,3,4-thiadiazole moiety. Many of the reported 2-amino-1,3,4-thiadiazole derivatives can be considered as lead compounds for drug synthesis, and several of them have demonstrated higher antimicrobial activity in comparison to standard drugs. Furthermore, taking into account the reactivity of the amine group in the derivatization process, 2-amino-1,3,4-thiadiazole moiety may be a good scaffold for future pharmacologically active 1,3,4-thiadiazole derivatives.

The paper analyzed the annual number of days with precipitation from 4 weather stations located in Maramureş County, during 1961-2016. The frequency of these days, their spatial and temporal variability, the decennial distribution of the number of days with precipitation, the trend and the assurance degree of the annual number of days with precipitation were also studied. The result was that in Maramureș County, between 157 and 194 days with precipitation occur on average per year. The mean annual number of days with precipitation increases from west to east, as the altitude of landforms increases, but also from south to north, as latitude increases. The analysis of the rainy and dry yearly intervals reveals the appearance of several extreme years towards the end of the analyzed period, in the last decade and a half (2000-2016). The linear trend of the annual number of days with precipitation is slightly increasing at the lowest station Baia Mare and decreasing at the other stations. The wettest decades were the 5th (2001-2010) and the 1st (1961-1970), and the driest decades were the 6th (2011-2016) and the 3rd (1981-1990). On the territory of Maramureş County, the values corresponding to the characteristic assurances (1, 2, 5, 10, 20, 25, 50, 80 and 100%) of the annual number of days with precipitation increase from west to east and from south to north. Once every 100 years, between 225 and 273 days with precipitation can occur in Maramureș.

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