Metastasis is resistant to conventional therapies and the main cause of death by cancer. In this article we discuss a non-autonomous model for the stage of cancer metastasis in which a periodic perturbation is introduced simulating the action of chronotherapy on the immune system and on the flow rate of the epithelial-mesenchymal transition. As a result of the perturbation, regions of less complexity are obtained, which implies less robustness or plasticity. These results allow us to delineate strategies for the chronotherapautic treatment in cancer metastasis.

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