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Objective:Study concentrations of steroid and thyreoid hormones in patients with neurotic, stress-related and somatoform disorders.Methods:35 patients with dissociative (conversion) disorders (ISD-10, F44), 29 patients with adjustment disorders (ISD-10, F43.2) and mentally healthy persons (27 persons) were investigated. Immunofermantal analysis for definition of concentration of steroid and thyreoid hormones were carried out.Results:We have observed statistically significant increased level of cortizol (p< 0,05) in patients with adjustment disorders (635,04±48,69 nmol/l) in comparison with control and patients with dissociative (conversion) disorders (444,97±24,53 nmol/l and 443,13±23,00 nmol/l accordingly). The statistically significant the lowered maintenance of dehydroepiandrosteronum is characteristic for patients with adjustment disorders in comparison with control and patients of another group (3,9±0,26; 6,35±0,62 and 6,69±0,50 mkmol/l accordingly, p< 0,05). For patients with dissociative (conversion) disorders is characteristic the statistically significant increased level of triiodthyronin (1,71±0,12 nmol/l), in patients with adjustment disorders and mentally healthy persons this metric composed 1,26±0,02 nmol/l and 1,34±0,04 nmol/l accordingly. The level of thyroxin for the persons with dissociative (conversion) disorders differ from values of control and patients with adjustment disorders (23,68±2,07 pkmol/l; 17,64±1,43 pkmol/l and 14,69±0,53 pkmol/l accordingly, p< 0,05).Conclusion:For patients with adjustment disorders is characteristic the statistically significant increased level of cortizol and the lowered maintenance of dehydroepiandrosteronum. Dissociative (conversion) disorders are formed in conditions of the raised maintenance thyreoid hormones and the physiological maintenance of steroid hormones.The investigation supported by project of RHSF №06-06-00691а, №07-06-95673и/М and №08-06-00284а.

Schizophrenia is a chronic disease resulting in disability, disturbance of adaptation in patient and his/her family.ObjectiveAnalysis of characteristics of adaptation based on authors’ many-level model of family functioning.Materials and methodsIdentification of quality of life of mental health care users, FACES-3, scales of prognosis of compliance in psychiatry (Lutova N. B. et al., 2007) and MARS. We have examined 152 schizophrenic patients (ICD-10 F2.0) and 38 their relatives.ResultsQuality of life of patients and relatives is affected; family are characterized by schizophrenic patients as a whole as balanced and middle-balanced in 82,35% of cases, as imbalanced - in 17,65%. Relatives of patients define families as balanced in 27,3%, as middle-balanced - in 54,5%, as imbalanced - in 18,2%. There are more middle-balanced families according to rating of probands and lesser balanced than relatives’ ratings. Imbalanced families are found almost with equal frequency. During the first hospitalization the insight of necessity of maintenance therapy, in opinion of patients, was found only in 27,6%; there was insight but they did not adhere recommendations of the doctor - 49,0%; there was not insight regarding meaning of doctor's prescription and they did not adhere doctor's recommendations - 23,4%. In the first year after the first hospitalization to psychiatric institution 55,0% persons have been re-hospitalized, out of them with non-compliance - 42,0%.ConclusionTraits of adaptive behavior of families in schizophrenia have been revealed.

The article deals with the peculiarities of the cerebral organization of subcortical structures in children with autism spectrum disorders. The study involved 48 children aged from 3 to 8 years (M=5.75; SD=2.61) having ICD-10 diagnoses F84.0, F84.1, F84.5. All children underwent registration of acoustic evoked brainstem potentials and neuropsychological examination. The relationship of the indicators of acoustic evoked potentials of the brain stem with the functioning of different blocks of the brain was established: the block of cortical tone and the brain energy block (Block I), the block of reception, processing and storage of exteroceptive information (Block II), the block of programming, regulation and control of the course of mental activity (Block III). For children with difficulties in activation and energy components of activity, perception of auditory information by subcortical structures of the brain causes certain difficulties (difficulties in work of the I block of the brain). Children with difficulties in right hemispheric holistic information processing strategy and a high level of its development are characterized by a reduced level of control over the course of thought activity, with difficulties in automating thinking and speech and difficulties in coordinating movements (difficulties in the work of Block II of the brain). The identified features of the cerebral organization of the processes of perception of auditory information and processes of mental activity in children with autism spectrum disorders are manifested in disorders of the course of thought activity, the function of peripheral receptors and conduction pathways to the cortical centers of the auditory analyzer, in a lowered level of control over the auditory analyzer. In connection with these processes there are difficulties with automatization of thinking and speech, coordination of movements in children.

Objective: We investigated biological and clinical-genealogical peculiarities in families of patients suffering from non-psychotic mental disorders with disturbance of respiratory system functionhyperventilation syndrome (HVS). Methods: We studied content of alveomucin in serum of blood of 43 patients from them 40 women and 3 men. Age was from 18 to 63 years. Genealogies of families of patients with indication of mental and somatic health of relatives were composed. Results: In personal assessment of patients in 39 from 43 cases (90%) hysteric traits of various degree of severity. In 18 cases HVS was manifested as vegetative crises while in 25 cases disturbances of respiration were not abruptly expressed but permanent. Concentration of alveomucin in persons with hysteric disorders constitutes 20,87±1,85, in patients with adjustment disorders with predominance of depressive reactions this index is 24,91±3,36, what is somewhat higher of content of alveomucin in mentally healthy persons (20,21±4,17). In families of patients relatives of first degree with personal peculiarities and mental disorders have been revealed as well as somatic diseases of organs of respiratory system. Conclusion: Non-psychotic mental disorders with disturbance of function of respiratory system are accompanied by increase of content of alveomucin in serum of blood of patients and mental peculiarities and diseases of respiratory system in nearest relatives.