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The ammonia content in the cerebral hemispheres and cerebellum of small susliks increases after the onset of hibernation, while the urea content decreases. The content of glutamine was increased after the second day of hibernation.Artificial cooling of the warm-blooded animal sharply disturbs the nitrogen metabolism of the brain [1-41. In rats adapted to cold, the ammonia content in the brain is increased [8, 9]. Hypothermia in such animals is characterized by a further increase in the ammonia concentration in the brain tissue. During hibernation (body temperature 17-16 and 11-10 ~ the ammonia concentration in the brain also is increased [7], The content of glutamine [7] and urea in the brain of these animals also varied depending on their body temperature. Accumulation of ammonia in the brain at a low body temperature can be considered to be of adaptive significance.In the present investigation the dynamics of the concentrations of ammonia and of glutamine and urea, which are connected with its metabolism, was investigated in relation to the period of hibernation. EXPERIMENTALExperiments were carried out on small susliks (Citellus pygmaeus Pallus), caught in the field (Dagestan) in May, 1968.The animals were kept in an animal house until the beginning of winter. In December, they were placed in individual cages, in near-natural conditions [5], and these were placed in a dark room at a temperature of 2-4 ~ Since the sleep of susliks falling into deep hibernation in December is not interrupted for a Tables 2 and 3, P was calculated relative to the preceding period of hibernation,

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Repeated cold stress performed in a cold-tempering mode reduces lipid peroxidation and activates tissue antioxidant system.

Short-term and prolonged (3 h) moderate (30 degrees C) hypothermia intensified oxidative modification of plasma proteins, while deep hypothermia (20 degrees C) decreased the intensity of this process to a control level. Preliminary intraperitoneal injection of dalargin had practically no effect on oxidative modification of plasma proteins during moderate hypothermia.