Introduction.There have been no studies, monitoring programs, or data about phthalate levels made available to the public on the safety of residential drinking water in Lagos, Nigeria.Objectives.The present study aimed to assess the concentrations of dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), and zinc (Zn), lead (Pb), chromium (Cr), and cadmium (Cd) in drinking water drawn from taps in three residential areas of the state.Methods.High performance liquid chromatography and atomic absorption spectroscopy were used to determine the concentrations of phthalates and metals, respectively.Results.All of the water samples collected throughout the sampling period contained DMP, while DEP and DBP were present in only some of the samples. The highest mean DMP, DEP, and DBP concentrations of 1.15±0.28 mg/l, 0.09±0.16 mg/l, and 0.28±0.33 mg/l, respectively, were found in water samples collected from Lagos Street (Ebute-metta East). In addition, the trace/toxic metal concentrations in the water samples were found to be low for Cr, but high for Cd, Pb, and Zn, especially when compared with World Health Organization (WHO) limit values for drinking water. Lead recorded the highest mean concentration of 0.087±0.021 mg/l in the water samples obtained from Apapa Road (Ebute-Metta West). In the same vein, the highest significant (P < 0.01) mean Cr concentration of 0.047±0.012 mg/l was found in the water samples obtained from Apapa Road (Ebute-Metta West).Conclusions.In view of the high concentrations of phthalates and metals in the water sampled in this study, and the potential adverse health effects of these contaminants, especially on children and women of child-bearing age, the Lagos State Government of Nigeria and the state water corporation are called upon to immediately institute a monitoring program to identify the sources of contaminants and take appropriate intervention measures.Competing Interests.The authors declare no competing financial interests.