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In total hip arthroplasty, a straight stem seems to provide better results than an anatomic one. A new generation of anatomic stems is under evaluation, so the followup is still short and cannot compare with studies of straight stems. The clinical and radiographic results of 176 patients who underwent 189 primary total hip arthroplasties using an anatomic, collared, proximally hydroxyapatite (HA)-coated femoral component were prospectively determined from 1 to 6 years follow-up. The stem is ribbed in the metaphyseal region, allowing to decrease the elasticity modulus, to augment the surface for bone ingrowth and to preserve the space needed for the circulation of the inner half side of the corticalis. The average postoperative Harris hip score was 96.7 points. All femoral components had radiographic evidence of bone ingrowth fixation at the final follow-up. There were no cases of loosening for any reason. The strength of the study is limited by the short follow-up, but our preliminary excellent clinical results with stable bone ingrowth fixation allow us to continue to use this stem following patients over time.Key words Anatomic stem • Total hip arthroplasty • Hydroxyapatite • Bone ingrowth lowed for one to six years after uncemented THA with an anatomic, titanium alloy, proximally hydroxyapatite (HA) coated femoral stem. Patients with Dorr's type A and B femura were enrolled in the study. The clinical and radiographic findings are presented. Materials and methodsWe reviewed the results of 196 primary cementless THAs, performed in 182 patients between April 1998 and October 2003. There were 72 men (39.5%) and 110 women (60.5%), of mean age 66.3 years (range, 58-89 years) and mean weight 73.2 kg (range, 52-96 kg). THA was indicated for a diagnosis of primary osteoarthrosis in 112 hips (57.2%), medial femoral neck fracture in 28 cases (14.3%), rheumatoid arthritis in 19 hips (9.7%),

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chondro-induction). Chondro-induction was lower (1.3AE0.4) and less reproducible when coculture was performed with M14 and did not occur with skin fibroblasts. GAG contents of constructs generated by solely macrophages were undetectable. Histological analyses of constructs confirmed the biochemical results. In the coculture there was no modulation of the chondrogenic genes. As compared to monocultures, in co-culture MSC and M24 numbers decreased less markedly (at day 7, MSC were 84% and 42% of the initial number, M24 were 26% of the initial number and undetectable, respectively for co-cultured and monocultured cells). Conclusions: We have demonstrated that coculture MSC/M42 results in synergistic cartilage tissue formation, which is not mediated by soluble factors alone. Further studies are envisioned to investigate whether M42 modulate the survival of specific MSC sub-populations. Finally, in vivo studies are necessary to assess the clinical relevance of our findings in the context of cartilage repair. Purpose: Brazilin is one major constituent of Caesalpinia sappan and is known to possess anti-bacterial, anti-oxidative, and anti-inflammatory activities. Osteoarthritis (OA) creates a disequilibrium between the catabolic and anabolic activities of chondrocytes in remodeling the Abstracts / Osteoarthritis and Cartilage 22 (2014) S57-S489 S148

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