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Rheumatic and connective tissue diseases in children at Santiago, ChileA collaborative ep.cerniclogical study o" pediatric rheumctic end connective tissue d'seases that were identified in patients aged 15 years or !ess (children] along year • 9

Background: Skin prick test (SPT) of immediate hypersensitivity is a main instrument in the diagnosis G1, 39% in GII and 65% in GIII (p <0.001). The predominant allergens for each group were dust mites (Dermatophagoides pteronissinus and farinae). Conclusions: SPT was useful when used on a selected pediatric population. The frequency of sensitization increased significantly with age. However, more than one third of children between 2 and 4 years of age tested positive to one or more allergen, demonstrating its applicability in this age group (Rev Méd Chile 2005; 133: 195-201).

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A six years old boy with Mixed Connective Tissue Disease is presented. Initial manifestations were Coombs positive hemolytic anemia, thrombocytopenia, Arthritis, liver and spleen enlargment.Search for antibodies to extiactable nuclear antigens (ENA) was positive for the ribonuclcase sensitive component (anti-RNP).This syndrome improved under corticosteroid therapy.To our knowledge this is the first report of such onset of MCTD in children.Clinical symptoms, laboratory manifestations and treatment of MCTD in children arc analized.