This review revealed that among all the natural and synthetic flavonoids, the inhibitory findings suggest that the flavonol moiety can serve as an effective and a lead structural scaffold for the further development of novel TIs.

DDQ is the most widely used quinone with a high reduction potential and it mediates hydride transfer reactions and shows three accessible oxidation states: quinone (oxidized), semiquinone (one-electron-reduced) and hydroquinone (two-electron-reduced).

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The present review focuses on various heterocyclic scaffolds and their role in designing and developing new potential AChE and BChE inhibitors to treat AD.