Tujuan: Menganalisis pengaruh pemberian gel ekstrak air daun pepaya terhadap kepadatan kolagen jaringan vagina pasca melahirkan pada hewan coba mencit saat bunting.Bahan dan Metode: Desain penelitian randomized post test only control group,dilakukan di Departemen Embriologi Veteriner, Fakultas Kedokteran Hewan, Universitas Airlangga, pada bulan April-Juni 2015. Terdapat empat kelompok, masing-masing kelompok terdiri dari 8 mencit bunting. Kelompok kontrol (tanpa perlakuan) dan kelompok perlakuan berupa pemberian topikal ekstrak daun pepaya konsentrasi 5%, 10% dan 15%, 1x/hari pervaginam, sejak usia kebuntingan hari ke-12 sampai melahirkan. Lama perlakuan 6-8 hari. Setelah melahirkan, mencit dikorbankan dan diperiksa kepadatan kolagen dengan pewarnaan HE. Uji statistik yang dipakai uji parametrik dan nonparametrik disertai uji komparasi gandaHasil: Kepadatan kolagen berdasarkan skor didapatkan nilai median pada kelompok I = 3,5 (3-4); kelompok II = 4 (4-4); kelompok III = 3 (3-4); kelompok IV = 4 (3-4) dengan uji Kruskal-Wallis (p=0,036) menunjukkan perbedaan signifikan, dilanjutkan uji beda tiap kelompok Mann-Whitney, hasilnya tidak didapatkan perbedaan signifikan antara kelompok kontrol dengan masing-masing kelompok perlakuan. Kepadatan kolagen berdasarkan persentase didapatkan nilai rerata pada kelompok I = 90,64%±3,35; kelompok II = 96,19%±1,34; kelompok III = 87,85%±6,69 dan kelompok IV = 92,08%±4,84. Uji Anova menunjukkan perbedaan signifikan (p=0,032), dilanjutkan uji beda LSD menunjukkan perbedaan bermakna antara kelompok I dan II (p=0,045)Simpulan: pemberian topikal ekstrak daun pepaya konsentrasi 5% pervaginam saat masa kebuntingan mencit meningkatan kepadatan kolagen jaringan vagina pasca melahirkan.

Objectives: to describe the profile of sexual function in post-menopausal women at Geriatric Clinic, Dr. Soetomo Hospital, Surabaya in May 2016 and to determine the factors of sexual dysfunction in 6 sexual domains.Materials and Methods: a descriptive study using survey to obtain data on the examined variables. Population in this study was all post-menopausal women at Geriatric Clinic of Dr. Soetomo Hospital, Surabaya, in May 2016. Data were obtained using Female Sexual Function Index (FSFI) questionnaire.Results: Total population in this study was 160 patients. The number of samples who met inclusion criteria were 90 patients, but only 37 were willing to participate. The prevalence of samples who were still active in sexual intercourse was 29.7%. Based on 6 sexual domains, the prevalence of the lack of desire was 48.6%, lack of arousal was 75.7%, lack of lubrication was 73%, lack of orgasm was 73%, lack of satisfaction was 73% and pain was 70.3%. The assessment of sexual function found that 78.4% of the samples were sexually dysfunctional.Conclusion: The high prevalence (78.4%) of sexual dysfunction in post-menopausal woman  was caused by dysfunction in sexual domain.

Objective: Comparing the clinical outcomes of laparoscopic and abdominal sacrocolpopexy in vaginal vault prolapse post-hysterectomy’s patient. Method: Systematic search data is performed on medical database (PUBMED, Cochrane Database) using keyword:(1) vault prolapse [title] AND (2) laparoscopic[title] AND sacrocolpopexy[title]. Inclusion criteria:(1) randomized controlled trial and observational studies, (2) women with vaginal vault prolapse post hysterectomy, (3) intervention studied: laparoscopic (LSC) and abdominal sacrocolpopexy (ASC), (4) the entire fully accessible papers can be accessed and data can be accurately analyzed. Comparison about clinical outcomes of LSC and ASC was performed using narrative analysis and meta-analysis (RevMan). Results: Three studies compared clinical outcomes of LSC and ASC with a total of 243 samples (118 in LSC and 125 in ASC group). There was no significant difference in the incidence of complications between LSC and ASC (OR 1.10;95%CI 0.58-2.08). LSC was associated with less blood loss (MD 111.64 mL,95%CI-166.13 - -57.15 mL) and shorter length of hospital stay (MD -1.82 days;95%CI -2.52- -1.12 days) but requires a longer operating time (MD 22.82 minutes,95%CI 0.43-45.22 minutes). There was no statistically significant difference to anatomical outcomes (measurement of point C on POP-Q), subjective outcomes measured by PGI-I and reoperation numbers (repeat surgical interventions) for prolapse recurrence between LSC and ASC groups after one year of follow-up. Conclusions: LSC showed similar anatomic results compared to ASC with less blood loss and shorter length of hospital stay in management patient with vaginal vault prolapse.