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Background: Congenital fetal anomalies were defined as any structural defect present at birth. Congenital fetal anomalies are an important causes of neonatal morbidity and mortality in developed and developing countries that affect health care system. Reliable data on these congenital anomalies are still lacking, especially in Indonesia. Objective: This study aims to determine the characteristic profile of congenital fetal anomaly in single tertiary hospital in East Java, Indonesia. Methods: Retrospective cross-sectional by using medical record data of dr. Soetomo General Hospital on January – December 2017. Results: There were 58 cases (4,3%) with fetal congenital anomaly from 1360 deliveries in 2017. The majority of cases were referral cases (51 cases; 88%) and only seven cases were booked cases in obstetric outpatient dr. Soetomo General Hospital. Most of these congenital fetal anomaly cases ( 25 cases / 43,1%) were born from mother with ages 20 – 30 years old. Most cases (34 cases; 58,64%) were diagnosed first at third trimester (gestational age > 28 weeks). There were 36 cases (62%) had active termination of pregnancy. Thirty eight percent (22 cases) were born at 37-42 weeks and majority were born section caesaria. The three highest proportion of organ systems involved in fetal congenital anomalies were those of abdomen (22 cases; 37,9%); head (20 cases; 34,5%); thorax and muskuloskeletal (each 12 cases; 20,7%). Conclusion: The incidence of congenital fetal anomaly in dr. Soetomo Hospital at 2017 was 4,3%. Omphalocele and CTEV were two most common types of congenital fetal anomaly found. Most cases of congenital fetal anomalies have a poor prognosis, 67% cases born died. Further research about  risk factors and comprehensive database are needed on cases of congenital anomaly to establish appropriate prevention and management.

Objective: Comparing the clinical outcomes of laparoscopic and abdominal sacrocolpopexy in vaginal vault prolapse post-hysterectomy’s patient. Method: Systematic search data is performed on medical database (PUBMED, Cochrane Database) using keyword:(1) vault prolapse [title] AND (2) laparoscopic[title] AND sacrocolpopexy[title]. Inclusion criteria:(1) randomized controlled trial and observational studies, (2) women with vaginal vault prolapse post hysterectomy, (3) intervention studied: laparoscopic (LSC) and abdominal sacrocolpopexy (ASC), (4) the entire fully accessible papers can be accessed and data can be accurately analyzed. Comparison about clinical outcomes of LSC and ASC was performed using narrative analysis and meta-analysis (RevMan). Results: Three studies compared clinical outcomes of LSC and ASC with a total of 243 samples (118 in LSC and 125 in ASC group). There was no significant difference in the incidence of complications between LSC and ASC (OR 1.10;95%CI 0.58-2.08). LSC was associated with less blood loss (MD 111.64 mL,95%CI-166.13 - -57.15 mL) and shorter length of hospital stay (MD -1.82 days;95%CI -2.52- -1.12 days) but requires a longer operating time (MD 22.82 minutes,95%CI 0.43-45.22 minutes). There was no statistically significant difference to anatomical outcomes (measurement of point C on POP-Q), subjective outcomes measured by PGI-I and reoperation numbers (repeat surgical interventions) for prolapse recurrence between LSC and ASC groups after one year of follow-up. Conclusions: LSC showed similar anatomic results compared to ASC with less blood loss and shorter length of hospital stay in management patient with vaginal vault prolapse.

Mual muntah pada kehamilan berlebih tidak hanya mengancam ibu hamil tetapi juga menyebabkan efek samping pada janin. Kader merupakan seorang yang sukarela sebagai pelaku penggerak masyarakat bukan tenaga professional tetapi hanya membantu dalam pelayanan kesehatan. Kegiatan pengabdian kepada masyarakat ini dilakukan untuk meningkatkan pengetahuan kader kesehatan tentang penanganan emesis gravidarum melalui pemanfaatan minuman herbal jahe. Sehingga kader diharapkan dapat memberikan edukasi tersebut kepada masyarakat. Pengabdian kepada masyarakat ini dilakukan di RW 1 Kelurahan Wonokromo Surabaya dengan melibatkan kader kesehatan sebanyak 23 orang yang dilakukan selama 1 bulan. Kegiatan pengabdian kepada masyarakat ini dilakukan dengan cara memberikan edukasi menggunakan power point dan leafleat tentang penanganan emesis gravidarum pada kader kesehatan melalui pemanfaatan minuman herbal jahe dengan menggunakan metode ceramah, tanya jawab dengan menerapkan protokol kesehatan. Sebelum pemberian edukasi, peserta kader kesehatan diberikan pretest dan setelah pemberian edukasi, diberikan posttest untuk mengukur tingkat pengetahuannya. Hasil dari kegiatan ini menunjukkan bahwa ibu kader kesehatan mempunyai tingkat pengetahuan yang baik setelah diberikan edukasi tentang penanganan emesis gravidarum melalui pemanfaatan minuman herbal jahe, dengan rata-rata skor pre test 34,8% sedangkan hasil post test nilai rata-rata peserta adalah 91,3% sehingga ada peningkatan pengetahuan kader kesehatan akan manfaat minuman herbal jahe untuk menurunkan mual muntah pada ibu hamil. Sehingga kader kesehatan diharapkan dapat secara mandiri memberikan edukasi kesehatan kepada masyarakat.   Kata kunci : Jahe, Mual Muntah, Kader Kesehatan   Abtract Nausea and vomiting in excess not only threatens pregnant women but also causes side effects to the fetus. A Kader is a person who voluntarily acts as a community mobilizer, not a professional but only assists in health services. This community service activity was carried out to increase the knowledge of health kader about handling emesis gravidarum through the use of ginger drinks. So that the kader are expected to provide this education to the community. This community service was carried out in RW 1, Wonokromo Village, Surabaya, involving 23 health kader, which was carried out for 1 month. This community service activity is carried out by providing education using power points and leaflets about handling emesis gravidarum to health kader through the use of ginger drink using the lecture method, question and answer using health protocols. Before giving education, health kader participants were given a pretest and after giving education, a posttest was given to measure their level of knowledge. The results of this activity indicate that the health kader mothers have a good level of knowledge after being given education about handling emesis gravidarum through the use of ginger drinks, with an average pre test score of 34.8% while the post test results have an average score of 91, 3 % so that there is an increase in the knowledge of health kader about the benefits of ginger herbal drink to reduce nausea and vomiting in pregnant women. So that health kader are expected to be able to independently provide public health education.   Keywords : Ginger, Nausea Vomiting, Health Cadre

Objectives The study aim is to evaluate the effect of pravastatin to prevent preeclampsia (PE) in pregnant women at a high risk of developing preeclampsia and the maternal and perinatal outcomes and the sFlt1/PLGF ratio in the Surabaya cohort of the INOVASIA trial. Setting This study involved 2 academic hospital (a tertiary and secondary center) in Surabaya, Indonesia. Participants Pregnant women at a high risk of developing PE were recruited and randomized into an intervention group (40) and a control group (40). The inclusion criteria consisted of pregnant women with positive clinical risk factor and abnormal uterine artery doppler examination at 10-20 weeks gestational age. Inteventions The control group received low dose aspirin (80 mg/day) and calcium (1 g/day), while the intervention group received additional pravastatin (20 mg twice daily) starting from 14-20 weeks gestation until delivery. Research blood samples were collected before the first dose of pravastatin, and just before delivery. Primary and Secondary Outcomes The primary outcome was the rate of maternal preeclampsia, secondary outcomes included maternal-perinatal outcomes and sFlt-1, PLGF, sFlt-1/PlGF ratio and sEng levels. Results The rate of preeclampsia was (non-significantly) lower in the pravastatin group compared with the control group (17.5% vs 35%). The pravastatin group also had a (non-significant) lower rate of severe preeclampsia, HELLP syndrome, acute kidney injury and severe hypertension. The rate of (iatrogenic) preterm delivery was significantly lower (p 0.048) in the pravastatin group (n=4) compared with the controls (n=12). Neonates in the pravastatin group had significantly higher birthweights, higher Apgar scores, and lower composite neonatal morbidity and NICU admission rates. All biomarkers show a significant deterioration in the control group compared with non-significant changes in the pravastatin group. Conclusions Pravastatin holds promise in the secondary prevention of preeclampsia and placenta-mediated adverse perinatal outcomes by improving the anti-angiogenic/pro-angiogenic imbalance. Trial Registration Clinical Trial Gov (ID: NCT03648970)