We recommend a minimally traumatic extraction technique, removal of any bone edges, and mucosal wound closure as standard procedures in patients receiving bisphosphonates. We find no evidence supporting the efficacy of a pre-extraction short-term drug holiday from oral bisphosphonates in reducing the risk of MRONJ.

KONDOU Eiji ・ TAKEKAWA Masanori ・ UTSUGI Chizuru YOSHIDA Masatsugu ・ SHIBAYAMA Naohiro ・ MATSUDA Mitsuyoshi : S-1 chemotherapy is widely used to treat head and neck cancer. Reports of interstitial pneumonia as a side effect of S-1 chemotherapy are very rare. We report a case of interstitial pneumonia possibly caused by S-1 treatment as postoperative adjuvant chemotherapy. We gave S-1 as postoperative adjuvant chemotherapy for mandibular gingival carcinoma in a 80-year-old woman. She had a fever 53 days after starting S-1 chemotherapy. The X-ray films and computed tomography (CT) showed reticular shadows in both lung fields, and the patient was given a diagnosis of interstitial pneumonia. The results of a drug-induced lymphocyte stimulation test were positive against S-1. The total dose of S-1 until the onset of symptoms was 3360 mg. We immediately started steroid therapy and withdrew S-1 chemotherapy, and then the symptoms remarkably improved, as did the abnormal findings on CT.

No abstract

The aim of this research was to analyze how the occlusal status of oral and maxillofacial cancer patients reconstructed with free scapular combined flap affects their oral function.Forty-seven patients treated in our hospital from 1988 to 2007 simultaneously underwent reconstructive surgery following mandibulectomy. Food intake was evaluated at least one year after treatment. The 47 patients were divided by means of Urken's classification. Most of the patients who underwent limited resection (B, BS) showed sufficient ability to eat without prosthetic dentures. Patients who became edentulous in a

We describe our experience with 4 patients who had squamous cell carcinoma of the soft palate treated by superselective intra-arterial chemoradiotherapy. Two patients had stage Ⅱ disease, and 2 had stage Ⅳ disease. Two of them presented regional lymph node metastatsis. All patients received cisplatin alone. The mean total dose of cisplatin was 461.3mg(300-600mg). Cisplatin was injected into the facial artery or the ascending palatal artery through the superficial temporal artery, with 200 mol times of sodium thiosulfate as the cisplatin neutralizer. All patients received radiotherapy in a dose of 66 Gy and had a complete response. The primary tumor recurred in 1 patient, but was successfully resected by salvage surgery. All patients were alive at an average follow-up of 58.6 months.