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Background: There is a growing population of geriatric men experiencing sexual health concerns. These issues may stem from surgical interventions of the prostate gland, age-related changes affecting erectile dysfunction, or other concerns. Objectives: To illuminate the male sexual dysfunctions lessened via pelvic floor muscle rehabilitation and proper education to assist clinicians in achieving positive patient outcomes. Methods: The literature was reviewed from 1996 to 2015 using PubMed. Results: Effective conservative care strategies exist for appropriate patients via pelvic floor muscle therapy, manual therapy, education regarding cardiovascular health, and triage to psychological and sexual counseling. Conclusion: Efficacy is present for this population, but some conditions are more effectively treated conservatively than others.

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INTRODUCTION AND OBJECTIVES: Despite accumulating evidence that long noncoding RNAs (lncRNAs) are associated with cancer development and drug resistance in multiple types of cancer, the biological roles of many lncRNAs in human clear cell renal cell carcinoma (ccRCC) develop and sunitinib resistant have not been well characterized.METHODS: At first, we established sunitinib resistant cell lines and then detected the differential lncRNAs by q-RT-PCR and found that ZFAS1 have higher expression in sunitinib resistant cells than parental cells. We separated the cytoplasm and nucleus of renal cancer cell lines to confirm the localization of ZFAS1. Western blot and luciferase assay were performed to verify that zfas1 can regulate EZH2 expression through competitively binding miR-30c-5p in ccRCC. RNA-seq analysis was used to identify differentially expressed mRNA in renal cancer cell lines transfected with sh-Lacz compared to cell lines transfected with sh-ZFAS1.RESULTS: We found that ZFAS1 expression was significantly upregulated in ccRCC tissues. In vitro and in vivo experiments revealed that ZFAS1 promoted renal cancer cell proliferation and metastasis. Knockdown ZFAS1 can also relieve renal cancer cell resistant to sunitinib. Further studies demonstrated that ZFAS1 could function as a competing endogenous RNA (ceRNA) by sponging miR-101-3p in ccRCC cells. The effect of sh-ZFAS1 was partially attenuated by miR-101-3p inhibitor on proliferation, metastasis and resistant to sunitinib. Moreover, further investigations disclosed that EZH2 was a downstream target of miR-101-3p and ZFAS1. EZH2 can also promote ccRCC cell proliferation, metastasis and resistant to sunitinib. The RNA-seq data implied that p-AKT pathway are downstream of ZFAS1-miR-101-3p-EZH2 axis.CONCLUSIONS: Overall, we concluded that the ZFAS1/miR-101-3p/EZH2/p-AKT axis may be a ponderable and promising therapeutic target for ccRCC.