A wide range of extremely effective chemotherapy drugs has a negative effect on the cardiovascular system, leveling the success of oncological treatment. Early diagnosis of cardiotoxicity is extremely important, allowing timely application of preventive and therapeutic measures. Evaluation of the left ventricular ejection fraction using echocardiography is the basic non-invasive instrumental method for assessing cardiac function and the main guideline in diagnosing cardiac dysfunction during chemotherapy. However, if dysfunction is subclinical the ejection fraction can remain normal for a long time, and also has a pronounced inter-operator variability and dependence on volumetric load. Specialists are constantly in search of optimal echocardiographic parameters that allow diagnosing cardiac dysfunction in the early stages. Analysis of the global longitudinal deformation of the left atrium seems to be a promising method for these purposes. A large amount of accumulated data suggests that the left atrium is not just a conduit chamber, but reflects the filling pressure of the left ventricle, being a sensitive marker of its systolic and diastolic dysfunction. This review presents an analysis of currently available studies on the application of the methodology for assessing the global longitudinal deformation of the left atrium in the diagnosis of cardiac dysfunction in use of cardiotoxic drugs.