The increasing number of people who survive in the long term because of the advanced of glioma therapy with chemotherapy causes more slowly emerging neurologic side effects. Currently, there were three medical treatments are approved by the FDA for the management of glioblastoma namely temozolomide, carmustine wafer, and bevacizumab. However, most of the traditional chemotherapy drugs have a target in cell proliferation and cause toxicity of healthy cells. The side effects of chemotherapy on central nervous systems are chemobrain, acute encephalopathy, leukoencephalopathy, cerebellar dysfunction, and spinal cord toxicity. In addition, severe chemotherapy side effects may also occur in the peripheral nervous system called Chemotherapyinduced peripheral neuropathic pain (CIPNP). The clinician should recognize the symptoms of those side effect in glioma patients who received chemotherapy.

Glioblastoma is the most common primary malignant tumor in the neural tissue and a highly aggressive primary tumor in human. It involves glial cells in 52% of functional brain tissue cases and 20% of all intracranial tumors. Extra cranial metastasis of Glioblastoma is very rare. Metastasis outside CNS was uncommon in GBM but it could occur with frequency 0.2% and can spread in head and neck sites. The mechanism of this spread is not understood yet. The extracranial spread routes were speculated on the direct lymphatic connections, the venous system and the adjacent structure like dura and bone. We present a case of female patient with a known glioblastoma who had an extracranial metastasis on her left neck with complete Radiotherapy n Chemotherapy and survive more than 2 years.

Stroke is a neurological function disorders caused by impaired blood flow in the brain

Latar belakang. Peningkatan kadar penanda faktor inflamasi setelah awitan stroke PIS mampu memprediksi keluaran klinis pada penderita Stroke Perdarahan Intraserebral PIS. Hingga saat ini, peran C-Reactive Protein (CRP) sebagai penentu prognosis pada stroke PIS masih belum jelas. Tujuan. Mengetahui hubungan antara kadar CRP terhadap keluaran klinis yang diukur dengan skala Indeks Barthel. Metode. Studi observasional dengan rancangan kohort porspektif pada penderita stroke PIS di RS Dr. Saiful Anwar Malang mulai Februari 2014 hingga April 2014. Hasil. Terdapat korelasi bermakna (p=0,05, r=0,613) antara kadar CRP dengan keluaran klinis yang buruk penderita stroke PIS yang diukur dengan skala Indeks Barthel. Simpulan. Peningkatan kadar CRP dapat memprediksi keluaran klinis buruk pada penderita stroke PIS yang diukur dengan skala Indeks Barthel.

Headache is the most common neurological disorder among all the symptoms of general health problems. Headaches are the most frequently complained of after back pain, which brings someone to the doctor and harms personal, family, social, quality of life, work, and finances. This study aims to find out the characteristics of primary headache patients in the neurological polyclinic, RSUD dr. Saiful Anwar Malang. The design of this research was an observational descriptive study of the filled headache questionnaire was to determine the characteristics of headache patients who visited the neurological polyclinic at dr. Saiful Anwar Malang with complaints of primary headache. The procedure of this research is to provide a questionnaire. The data analysis technique used is that the research variables will be presented in the frequency distribution table. The results of this research show that primary headache was more common in women as many as 19 people (61%) compared to male 12 people (39%). Most of the primary headache patients who came to the neurological clinic of Saiful Anwar Hospital were 30-60 years old. Tension-Type Headache (TTH) in this study had the highest percentage of 58%. In this study, cluster headache two patients all attacked women.