We report Muscope, a miniature lensless holographic microscope suitable for on-chip integration. The prototype of Muscope measured approximately only 7 mm x 4 mm x 4 mm, yet was capable...
We report the fabrication of very thin microfluidic active and passive devices on rigid and flexible substrates for sample-space-restricted applications. Thin glass coverslips are commonly used substrates, but these being fragile often crack during experiments, leading to device failure. Here, we used PET as a flexible substrate to fabricate robust thin devices. We proposed a simpler process for PET-PDMS bonding without any silane, adhesive, and/or plasma treatment. We presented the compatibility of the thin devices with a digital in-line holographic microscope (DIHM) as a use case. The substitution of the conventional microscope with DIHM in microfluidic large-scale integrated systems renders simplicity, cost effectiveness, portability, and miniaturization of the overall system. It also enables a customized and parallel multisite optical observation for a complex microfluidic circuit chip. These chips comprise various microfluidic components made of active microvalves, particularly Quake valves. We also successfully demonstrated the function of microvalves fabricated with our method to regulate the fluidic flow. Thus, are suited to making sophisticated microfluidic circuit chips to fit a variety of applications like organ-on-chip, cell culture, wearable biosensors, pressure sensors, etc.
Aggressively scaled SRAM is highly vulnerable to short channel and process variation effects. FinFET technology emerges as a device level solution to overcome these scaling limitations while assist techniques aid super-scaled SRAM to achieve better performance and stability. In this paper, we propose two operation-aware assist circuits, namely, Split and Suppressed cell Supply (SSS) and Negative Bit-Line scheme incorporated SSS (SSS-NBL) to provide better write performance without compromising read performance. We exploit cell supply collapse scheme in SSS to achieve low power consumption and improved write performance whereas SSS-NBL further ameliorates write performance. A new analytical model is derived for SSS-NBL. Simulation results reflect an improvement of 0.53% in read performance of 6T SRAM cell whereas 34.02% and 27.86% in write performance using SSS for 6T and PPN-based 10T SRAM cell, respectively. Similarly, SSS-NBL offers 37% and 32.63% improved write performance over 6T and PPN-based 10T bitcell, respectively.
In the past few decades, a significant amount of effort has been put into developing different lensless microscope designs. The existing lensless microscopes are capable of offering high resolution and wide field-of-view using super-resolution and computational techniques. But, the employment of macroscopic illumination system and unscalable opto-mechanical components limit their cost-effectiveness, scalability, mass production and on-chip integration. In this work, we report Muscope, an on-chip microscope, which fixes these issues. It extends a few mm in each dimension and comprises of an off-the-shelf electronic assembly. The futuristic microLED display chip is utilised as the light source. Each microLED on the chip functions as a microscopic light source whose position and rightness can be electronically controlled. To demonstrate Muscope, we imaged human blood smear and microbeads of diameter upto 1 um. We also provide a proof-of-concept of its suitability with super-resolution and field-of-view enhancement techniques, without additional hardware compulsions.
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