One hundred chicks, one day old were divided into 10 groups. The first group was control negative and the second was control positive (infected with E. coli O 78). The other eight groups treated either by Thymus vulgaris (1 or 2 ml/ 1 litter drinking water) or zingiber officinale (5 or 10 ml/ 1 litter drinking water) from the first day old till the end of the experiment. Experimental infection was done orally to 4 groups only of the 8 groups at 10 days old. Biochemical profiles showed better results with higher doses of either Thymus vulgaris or zingiber officinale extract in comparision with lower doses of the same extract either in infected with E.coli O78 or natural not infected chicks. The treated experimentally infected groups showed better results than compare to positive control group. These biochemical results are confirmed by the histopathological pictures that prepared by taking specimens from intestine, kidneys, liver, lung, spleen, thymus, and bursa of Fabricious. The microscopic examination cleared pathological changes in the control positive also the infected treated groups with lower doses of any of the two extracts. On the other hand, the infected treated groups with higher extracts doses showed better improvements in the microscopic pictures than the infected treated with lower doses.