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Increasing evidence suggests that perceived social isolation or loneliness is a major risk factor for physical and mental illness in later life. This review assesses the status of research on loneliness and health in older adults. Key concepts and definitions of loneliness are identified, and the prevalence, correlates, and health effects of loneliness in older individuals are reviewed. Theoretical mechanisms that underlie the association between loneliness and health are also described, and illustrative studies examining these mechanisms are summarized. Intervention approaches to reduce loneliness in old age are highlighted, and priority recommendations for future research are presented.

This study introduces the Daily Inventory of Stressful Events (DISE), an interview-based approach to the measurement of multiple aspects of daily stressors through daily telephone interviews. Using a U.S. national sample of adults aged 25 to 74 (N = 1,031), the prevalence as well as the affective and physical correlates of daily stressors are examined. Respondents had at least one daily stressor on 40 percent of the study days and multiple stressors on 11 percent of the study days. The most common class of stressors was interpersonal tension followed by work-related stressors for men and network stressors (events that occur to close others) for women. Stressors that involved danger of loss were more prevalent than stressors in which loss actually occurred. Regression analyses showed that specific types of daily stressors such as interpersonal tensions and network stressors were unique predictors of both health symptoms and mood.

We draw on the theory of allostasis to develop an integrative model of the current stress process that highlights the brain as a dynamically adapting interface between the changing environment and the biological self. We review evidence that the core emotional regions of the brain constitute the primary mediator of the well-established association between stress and health, as well as the neural focus of "wear and tear" due to ongoing adaptation. This mediation, in turn, allows us to model the interplay over time between context, current stressor exposure, internal regulation of bodily processes, and health outcomes. We illustrate how this approach facilitates the integration of current findings in human neuroscience and genetics with key constructs from stress models from the social and life sciences, with implications for future research and the design of interventions targeting individuals at risk.