Among preterm lambs with severe RDS, lucinactant produced improvements in gas exchange and lung mechanics similar to those observed with a porcine-derived surfactant.

Partial liquid ventilation with perfluorocarbon could be a good noninvasive alternative technique that improves gas exchange and pulmonary mechanics in meconium aspiration syndrome without impairing cardiovascular function.

Financial Disclosure: We too freely declare potential conflict of interest, because we received support from Discovery and Esteve Laboratories to perform these experiments, but we have also received support from Chiesi, for basic and for clinical studies as well as consultancy fees.