A flow piezoquartz immunosensor was developed for the rapid estimation of 4-aminophenol in pharmaceutical formulations based on paracetamol. The bioreceptor coating was a 4-aminophenol-protein conjugate (4-AP-GA-BSA), immobilized on the silanized surface of a silver electrode. The effects of the concentration of polyclonal antibodies on the analytical signal of the sensor were studied: the activities of immunological reagents were assessed in terms of the binding constant K b . A method for flow-injection estimation of 4-aminophenol in pharmaceutical formulations using the piezoquartz immunosensor as the detector was developed. The calibration curve was linear over the concentration range 2 -120 ng/ml and the detection limit for 4-aminophenol was 1.1 ng/ml. 220 0091-150X/08/4204-0220

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