HSV genital shedding measured by PCR analysis in swab specimens self-collected daily is an appropriate surrogate outcome for genital herpes lesions because it is in the causal pathway to recurrences.

US Food and Drug Administration-approved EIAs have poor PPV for HSV-2 and poor NPV for HSV-1 in clinical practice. More accurate rapid type-specific HSV antibody tests are needed.

HIV infection is a significant independent risk factor for severe COVID-19 disease and death. We summarize COVID-19 vaccine responses in people living with HIV (PLHIV). A systematic literature review of studies from 1 January 2020 to 31 March 2022 of COVID-19 vaccine immunogenicity in PLHIV from multiple databases was performed. Twenty-eight studies from 12 countries were reviewed. While twenty-two (73%) studies reported high COVID-19 vaccine seroconversion rates in PLHIV, PLHIV with lower baseline CD4 count, CD4/CD8 ratio, or higher baseline viral load had lower seroconversion rates and immunologic titers. Data on vaccine induced seroconversion in PLHIV are reassuring, but more research is needed to evaluate the durability of COVID-19 vaccine responses in PLHIV.

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