Estrogen has anti-oxidative and anti-inflammatory properties, but its levels decrease in postmenopausal women who can trigger oxidative stress. One of the most damaging effects of ROS is lipid peroxidation, and the end product is Malondialdehyde (MDA). Similarly, aging endothelium has increased oxidative stress and endothelial cell sensitivity to apoptosis. This study aimed to determine the effect of cowpea extract on serum MDA levels, aortic endothelial cell counts, and brain MDA levels in the ovariectomy model. Cowpea extract can be used as an alternative to prevent and overcome the effects that occur during menopause, such as cardiovascular problems, decreased bone mineral density, and dementia. The study used 15-month-old female Rattus norvegicus, divided into six groups (OVX, SHAM, OVX+estradiol, OVX+Vu 1.25; 2.5; and 5 mg/kg BW/day). Serum and brain MDA levels were examined by ELISA method, while the number of aortic endothelial cells were examined on histopathological preparations with Hematoxylin & Eosin (HE) staining. The mean value of serum and brain MDA levels decreased with an increase in the dose given (p-value 0.016). The mean value of aortic endothelial cells between the dose groups did not significantly differ. However, the mean value showed an increasing trend as the dose of cowpea extract was given. The results of this study indicate that the extract of cowpea has the potential as an antioxidant to reduce serum and brain MDA levels, prevent a decrease in the number of aortic endothelial cells. As prevention, cowpea extract can be used as an antioxidant and consumed since premenopause to minimize problems that occur during postmenopause.
Pendidikan seks pada anak yang masih dianggap tabu berdampak pada tingginya kasus kekerasan maupun pelecehan seksual pada anak. Beberapa kasus kekerasan seksual yang terjadi pada anak telah diidentifikasi bahwa anak tidak tahu dan tidak menyadari tindakan yang dilakukan oleh pelaku kekerasan seksual merupakan tindakan yang salah. Maka dari itu, pendidikan seks penting diberikan pada anak usia sekolah. Kegiatan pengabdian masyarakat yang dilakukan adalah pemberian edukasi mengenai perubahan masa pubertas dan upya perlindungan diri untuk pencegahan kekerasan seksual pada anak. Metode edukasi yang digunakan yaitu Small Group Discussion (SGD) dan video (audiovisual). Hasil pre-test menunjukkan hanya terdapat 15% anak yang mengetahui perubahan masa pubertas dan upaya perlindungan diri untuk mencegah kekerasan seksual. Proses SGD dilakukan sesuai langkah dan diskusi berjalan sesuai dengan tujuan yang ingin dicapai. Ketka pemaparan video, siswa memperhatikan dengan seksama. Hasil post-test menunjukkan bahwa 70% siswa telah mengetahui perubahan masa pubertas dan upaya perlindungan diri untuk mencegah kekerasan seksual.
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