RESUMOO presente trabalho teve a finalidade de abordar a prospecção tecnológica da produção de Ácido Hialurônico (AH) por meio de microrganismos. Foram mapeados em bases de dados internacionais as patentes e artigos sobre a temática, a fim de verificar a maturidade tecnológica e outros aspectos desse processamento microbriano do AH. Dos resultados obtidos constatou-se que a utilização de bactérias é muito comum, especialmente as da espécie Streptococcus sp e sua subespécie Streptococcus zooepidemicus, seguidas da espécie Bacillus sp. Como alternativas, ainda que embrionárias, as leveduras geneticamente modificadas têm surgido como microrganismos alternativos no processo de obtenção de AH, destacando-se a Pichia pastoris. Ao analisar os aspectos da prospecção, conclui-se que a tecnologia de produção de AH por microrganismos quando utilizadas bactérias é madura, e embrionária, porém promissora, quando considerado o uso de leveduras recombinantes.Palavras-chave: Microrganismos. Ácido Hialurônico. Prospecção tecnológica. TECHNOLOGICAL PROSPECTION OF THE PRODUCTION HYALURONIC ACID BY MICROORGANISMS ABSTRACTThe aims of this paper was verify technological prospection aspects of the Hyaluronic Acid (HA) production by microorganisms. Patents and articles on the subject have been mapped in international databases in order to verify the technological maturity and other aspects of this microbriano processing of HA. From the results it was find that the use of bacteria is very common, especially the species Streptococcus sp and its subspecies Streptococcus zooepidemicus , followed by the species Bacillus sp. Although embryonic, genetically modified yeasts have emerged as an alternative microorganism in the process of AH production, especially Pichia pastoris. In analyzing aspects of the prospection, it is concluded the technology of HA production by microorganisms is mature when bacteria's are used, and embryonic, but promising, when considered the use of recombinant yeasts.
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