found that at a 5-month lag, the Ekman component mainly contributes to the southern part of the dipole and cumulative air-sea fluxes only explain a small fraction of the SSTA variability. Given that the southern part of the SSTA dipole encompasses the main development region for Atlantic hurricanes, our results therefore suggest the potential for AMOC observations from 26 • N to be used to complement existing seasonal hurricane forecasts in the Atlantic.

In response to minimum retroreflectivity standards, transportation departments are implementing sign asset management strategies, which rely upon knowledge of how retroreflectivity decreases as signs weather and age. To provide this knowledge, the authors field-measured over 1000 inservice signs in scattered North Carolina Department of Transportation (NCDOT) divisions, collecting age and retroreflectivity data for white, yellow, red, and green signs and for ASTM sheeting Types I and III. Data from this study and data from five similar US efforts were analyzed using regression to identify the best available deterioration rate estimates, finding that retroreflectivity minimums are usually reached 8 to 15 years after installation.Initial results indicated that the best-fitting relationships between retroreflectivity and age were generally linear and that these models were significant despite having low R 2 values. Because age did not explain some of the variance, the authors re-evaluated their data including NCDOT divisions as a factor, finding that sign deterioration differed significantly by division, indicating that handling practices, manufacturing differences, and environmental exposure may be key deterioration model factors that merit future study.

No abstract

Background: Traumatic brain injury (TBI) remains a significant risk factor for post-traumatic epilepsy (PTE). The pathophysiological mechanisms underlying the injury-induced epileptogenesis are under investigation. The dentate gyrus—a structure that is highly susceptible to injury—has been implicated in the evolution of seizure development. Methods: Utilizing the murine unilateral focal control cortical impact (CCI) injury, we evaluated seizure onset using 24/7 EEG video analysis at 2–4 months post-injury. Cellular changes in the dentate gyrus and hilus of the hippocampus were quantified by unbiased stereology and Imaris image analysis to evaluate Prox1-positive cell migration, astrocyte branching, and morphology, as well as neuronal loss at four months post-injury. Isolation of region-specific astrocytes and RNA-Seq were performed to determine differential gene expression in animals that developed post-traumatic epilepsy (PTE+) vs. those animals that did not (PTE−), which may be associated with epileptogenesis. Results: CCI injury resulted in 37% PTE incidence, which increased with injury severity and hippocampal damage. Histological assessments uncovered a significant loss of hilar interneurons that coincided with aberrant migration of Prox1-positive granule cells and reduced astroglial branching in PTE+ compared to PTE- mice. We uniquely identified Cst3 as a PTE+-specific gene signature in astrocytes across all brain regions, which showed increased astroglial expression in the PTE+ hilus. Conclusions: These findings suggest that epileptogenesis may emerge following TBI due to distinct aberrant cellular remodeling events and key molecular changes in the dentate gyrus of the hippocampus.

There is a paucity of preclinical models that simulate the development of ovarian tumors in humans. At present, the egg-laying hen appears to be the most promising model to study the spontaneous occurrence of ovarian tumors in the clinical setting. Although gross classification and histologic grade of tumors have been used prognostically in women with ovarian tumors, there is currently no single system that is universally used to classify reproductive tumors in the hen. Four hundred and one 192-wk-old egg-laying hens were necropsied to determine the incidence of reproductive tumors using both gross pathology and histologic classification. Gross pathologic classifications were designated as follows: birds presenting with ovarian tumors only (class 1), those presenting with oviductal and ovarian tumors (class 2), those with ovarian and oviductal tumors that metastasized to the gastrointestinal tract (class 3), those with ovarian and oviductal tumors that metastasized to the gastrointestinal tract and other distant organs (class 4), those with oviductal tumors only (class 5), those with oviductal tumors that metastasized to other organs with no ovarian involvement (class 6), and those with ovarian tumors that metastasized to other organs with no oviductal involvement (class 7), including birds with gastrointestinal tumors and no reproductive involvement (GI only) and those with no tumors (normal). Histopathologic classifications range from grades 1 to 3 and are based on mitotic developments and cellular differentiation. An updated gross pathology and histologic classification systems for the hen reproductive malignancies provides a method to report the range of reproductive tumors revealed in a flock of aged laying hens.