Bilateral phacoclastic uveitis caused by lenticular infection with Encephalitozoon cuniculi is described in a snow leopard. The diagnosis was made on histopathological and immunohistological examination of both eyes submitted after postmortem examination. There was a positive antibody titer for E. cuniculi (1:320). Polymerase chain reaction (PCR) and sequence analysis of formalin-fixed, paraffin-embedded ocular tissue detected the DNA of E. cuniculi, strain III. No other systemic lesions attributable to the E. cuniculi infection were identified.

A 4‐year‐old, male Rothschild's giraffe presented with a rapidly growing, hemispherical, approximately 40 × 20 × 20 mm, raised, firm mass located on the mid‐region of the left lateral thigh. Complete surgical excision (minimal 20 mm margins in all orientations) was achieved under behavioural restraint and local anaesthesia. Cytology and histopathology diagnosed a poorly differentiated malignant mesenchymal neoplasm, with nuclear karyomegaly, multinucleation and atypical horseshoe‐like forms. The neoplastic cells exhibited diffuse strong cytoplasmic immunopositivity to vimentin, and were negative to smooth muscle actin, desmin, glial fibrillary acidic protein, and CD18 immunomarkers, giving a diagnosis of undifferentiated pleomorphic sarcoma. At 1 year follow‐up, the giraffe is clinically well with no health issues after complete excision, and no evidence of local recurrence or distant metastases, based on physical examination and routine haematology/biochemistry. To the authors’ knowledge, this is the first report of an undifferentiated pleomorphic sarcoma (atypical fibroxanthoma‐subtype) in a giraffe.

Case description A 17-year-old female western lowland gorilla presented with bilateral ocular discharge, conjunctivitis, and rhinitis that was investigated and treated over a 34-month period. Clinical findings, diagnostic results, treatment, and follow-up are described. Clinical finding A mild intermittent mucoid ocular discharge was initially noted. 10 months later, conjunctival hyperemia and thickening developed and progressed rapidly to a mass-like lesion covering the right eye. Hematology revealed eosinophilia. Conjunctival cytology revealed eosinophils and neutrophils, and histopathology revealed a chronic proliferative eosinophilic conjunctivitis. 21 months after, the ocular lesions were investigated the gorilla developed masses within both external nares. Histopathology of the nasal lesions revealed chronic-active eosinophilic rhinitis. Treatment and outcome Treatment of the gorilla was based on protocols recommended for human patients. Protocols for mild, moderate, and finally severe disease were used, involving topical and oral combinations of treatments. The gorilla eventually responded to systemic immunosuppressant therapy recommended for severe refractory disease. Clinical significance To the authors' knowledge, this is the first reported case of vernal-like conjunctivitis in a western lowland gorilla. History and signalmentA 17-year-old female western lowland gorilla (weight 85.7 kg; Gorilla gorilla gorilla) developed bilateral ocular discharge, conjunctivitis, and rhinitis that was investigated and treated over a 34-month period. The only prior medical history was a single episode of mastitis after giving birth 3 years previously.

A 10‐year‐old male cheetah (Acinonyx jubatus) presented with weight loss, inappetence and weakness. Clinical examination revealed muscle loss, splenomegaly and dehydration. Haematology and biochemistry showed hyperglobulinaemia and marked leukocytosis with eosinophilia and neutrophilia. Urinalysis revealed proteinuria. Following an empirical 7‐day course of clavulanate potentiated amoxicillin, normal appetite and demeanour were observed. One month later, it re‐represented with the same clinical signs. Clinical examination was repeated. Radiographs showed ileocaecocolic junction dilation. Ultrasound examination revealed enlarged mesenteric lymph nodes, splenic nodules and colonic thickening. Fine‐needle aspirates of these organs and bone marrow aspirates showed marked atypical eosinophilic infiltration with haematology showing peripheral eosinophilia. Idiopathic hypereosinophilic syndrome was diagnosed. Treatment with prednisolone was initiated with good compliance, but there was a marked clinical deterioration 2 days later, and euthanasia was elected on welfare grounds.