Introduction: Carotid intima-media thickness (CIMT) is a predictor marker of subclinical atherosclerosis that can be measured by ultrasound technique. The clinical symptoms of atherosclerosis usually begin with the thickening of the carotid artery walls. Polymorphism in Apolipoprotein E4 (APO-E4) is considered to be an important genetic determinant of atherosclerosis and Coronary Artery Disease (CAD). The genetic role of APO-E4 on plasma lipid has shown that the APO-E4 allele is associated with increased plasma LDL and total lipid concentration. The main objectives of this study were to identify genotype polymorphisms of the APO-E gene and measure the thickness of the carotid intima in subjects with APO-E4 polymorphisms in the first descendant of coronary heart patients. Patients and methods: A cross-sectional study design was used to determine the polymorphism of the APO-E4 genotype in the first descendant of CAD and non-CAD groups. There were 21 samples in each group. Gene polymorphism examination was carried out by PCR and the CIMT was measured with doppler ultrasound. Results: The result showed that 21.4% of subjects had polymorphism of the APO-E4 genotype with a significant difference between CHD and non-CHD group. This data shows that the APO-E4 genotype is more dominant in the first descendant of patients with CHD when compared to non-CHD parents. The mean values of CIMT ini right and left-sided carotid arteries among APO-E4 genotype and non-APO-E4 genotype were 0.4743 mm vs. 0.4195 mm and bivariate analysis showed a significant difference with a P-value of 0.017. This shows that there is a significant difference in the thickness of the carotid intima in the first descendant of subjects who have the APO-E4 genotype and those who do not. Conclusion: The APO-E4 gene polymorphism was more dominant in the first descendant of CAD patients with a higher CIMT mean value.

After the COVID-19 pandemic is ongoing up to 3 years, finally Indonesia started experience transition from pandemic going to endemic, following decreasing of case positive for COVID-19. During the transition, a number of rule start relaxed, however government recommend public for still carry out health protocol. Besides, in field education, all school carry out 100 % offline learning. The students have to stay alert from COVID-19 infection or another infection. So that, clean and healthy lifestyle (PHBS) is necessary carried out at school. There are several indicators of PHBS in schools that are necessary known by students. This health education aims to give education to 97 students in schools especially at SMK Negeri 2 Bengkulu City about importance implementing PHBS in the transition period of COVID-19 pandemic. This activity took place on Thursday , 22 September 2022. The method used form give education and discussion regarding PHBS in schools. We evaluated student’s understanding by pre-test and post-test about PHBS. Participant generally already have own knowledge regarding PHBS and more understand PHBS after participated in this activity.

Tradisional medicine is a part of Indonesian medicine cukture. As ginger is known to affect blood lipid profile, especially red ginger (Zingiber officinale var. rubrum) with a higher volatile oil content than other types of ginger. Meanwhile, dyslipidemia is a state of abnormal blood lipid profile levels. This research was conducted at RSUD dr. M. Yunus Bengkulu in 2014. Subjects were dyslipidemia with diabetes mellitus type 2 patients in age range 30-60 years. The total subjects in this study were 10 patients with simple random sampling grouping method. Then thay were devided into control group and treatment group. Neither group received standard drug therapy. The dried red ginger powder was only given to the treatment group at a dose of 3 grams per day for one month.. Both groups examined the LDL (Low Density Lipoprotein), trigliseride and HDL (High Density Lipoprotein) levels before and after the study. Changes to LDL, trigliseride and HDL levels were tested by independent sample test with a significance value of p 0.05. From the research that has been done is known that the dried red ginger powder not significantly affect LDL, trigliserida and HDL (p LDL=0,261; p Trigliserida=0,966; p HDL= 0,175). Based on the statistical analysis, it is known that the dried red ginger powder not significantly affect LDL, trigliserida and HDL. Descriptive analysis showed a decrease in triglyceride levels. Deskriptive analysis shows that the dried red ginger powder can inhibit the incerase to LDL, can reduce triglyceride and inhibit the decrease to HDL.