Background: Subcutaneous infliximab and vedolizumab formulations have been developed for maintenance therapy in inflammatory bowel disease. The objective of this study was to explore the inflammatory bowel disease patient’s acceptance for switching from intravenous infliximab or vedolizumab to subcutaneous, as well as to describe the causes of refusal or, conversely, the factors associated with acceptance. Methods: Patients were prospectively recruited between June 2021 and March 2022 during their infusion of infliximab or vedolizumab in the Medical Day Hospital of Nancy University Hospital. Adult patients with an established diagnosis of inflammatory bowel disease in clinical remission were eligible for inclusion in this study if they had been treated with intravenous infliximab or vedolizumab for at least six months. Results: One hundred and thirty patients were included in this study. Thirty-six patients (27.7%) received vedolizumab and ninety-four patients (72.3%) received infliximab. Median duration of treatment at inclusion was 7.0 years [3.0–11.0]. In this cohort, 77.7% of patients accepted the switch from intravenous infliximab or vedolizumab to subcutaneous. The main reasons for patient’s refusal for switching from intravenous to subcutaneous formulation were fear of loss of efficacy, a more spaced-out medical follow-up, increased frequency of administration, and self-administered injection. A short duration of treatment was associated with a high switch acceptance rate (odd ratio (OR) (95% confidence interval (CI)) = 0.9 (0.8–0.9); p = 0.0002). Conclusion: A large majority of the patients included accepted the switch of their treatment with infliximab or vedolizumab from the intravenous form to the subcutaneous form. This study identified one predictor influencing the acceptance rate in inflammatory bowel disease population: short treatment duration. Subcutaneous infliximab and vedolizumab hold potential for greater patient flexibility by self-administration, reducing travel and hospital attendance for infusion.

Billions of children/adolescents experienced unprecedented changes in their daily lives that impacted their health-related quality of life (HRQoL) during the first wave of the coronavirus disease 2019. The purpose of this study was to describe child-parent discrepancies in reporting on HRQoL and explore factors associated with such discrepancies at the end of the first lockdown in France. A cross-sectional study was conducted among French school-aged children from 8 to 18 years and their parents living in the Grand Est region in France during the first wave of the epidemic. The impact of individual, self-reported health status and environmental data on discrepant parent–child reports of HRQoL was assessed by multinomial multivariable logistic regression models. A total of 471 parent–child pairs were included. Among 50% of the discordant pairs, parents underestimated HRQoL more frequently than they overestimated it. Home location, social support score, children’s education level, parents’ education level, tensions and conflicts with neighbors reported by children, whether they had access to a garden, and parents’ professional activity were significantly associated with parental overestimation (adjustedOR from 2.08 to 11.61; p < 0.05). Factors associated with parental underestimation were children’s education level, SF12 score, home location, the child’s gender, parent’s level of education, the presence of noise in the residence reported by children, whether a household member was infected with COVID-19, whether they had access to a garden, and family structure (adjustedOR from 1.60 to 4.0; p < 0.05). This study revealed differences between child-reported and parent-reported HRQoL. The COVID-19 pandemic accentuated the discrepancies in observable dimensions and attenuated them in unobservable dimensions of HRQoL but did not impact the directional discrepancy; parents underestimated their child’s HRQoL more. These discrepancies appear to be explained by parent and child sociodemographic factors.

Objective: To evaluate the impact of antenatal corticosteroid therapy (ACS) on birth parameters of full-term newborns exposed during pregnancy for prematurity threat. Study Design: Exposed newborns were randomly compared to non-exposed controls in a 1-to-2 design. Data were retrospectively collected in infants’ files. Multivariate analysis assessed the impact of ACS on neonatal outcome. Result: 408 term born neonates were included, 136exposed to ACScompared to 272 non-exposed controls. Mean+/-SD Head Circumference (HC) was 33.7+/-1.4 vs 34.3+/-1.6 cm, p=0.001in exposed vs controls; birth weight (BW) 3.1+/-0.4 vs.3.3+/-0.4 Kg; p = 0.0001; Birth Height (BH) 47.9+/-2.1 vs. 49.1+/-2.0 cm; p<0.0001. Hypocalcemia (4.4 vs 0.7% p=0.019) and eating difficulties (5.1 vs 1.5% p=0.047)were significantly higher in exposed newborns. Multivariate analysis for HC showed a significant independent association with ACS(β=-0.5, p=0.009). Conclusion: Term neonates exposed to ACS have a smaller HC at birth and a higher risk of neonatal complications.

ObjectivesBillions of children and adolescents experienced unprecedented changes in their daily lives that impacted their health-related quality of life during the first wave of coronavirus disease 2019. The purpose of this study was to describe child-parent discrepancies in reporting quality of life and explore factors associated with such discrepancies at the end of the first lockdown in France. Methods A cross-sectional study was conducted among French school-aged children from 8 to 18 years and their parents living in the Grand Est region in France during the first wave of the epidemic. Data were obtained through an online survey. Child-reported and parent-rated health-related quality of life were assessed by the KIDSCREEN-27 scale. Sociodemographic data, living and learning conditions data and parent’s levels of anxiety, stress, social support, quality of life and resilience were also collected. Multinomial multivariate logistic regression analyses were used to determine the factors associated with discrepant parent-child reports of health-related quality of life. ResultsA total of 471 parent-child pairs were included. In each dimension, there were about 50% of discordant pairs which ranged from 42.9% for the physical well-being dimension to 51.8% for the peers and social support dimension. There were more discrepancies in the sense of under-estimation of the quality of life of children by parents, which ranged from 30.8% for the autonomy and parents’ dimension to 41.4% for the physical well-being dimension, than over-estimation. Factors associated with parental overestimation included tensions and conflicts with neighbors reported by children for physical well-being dimension, parents' professional activity (whether they work full time, part time or not at all) and MSPSS significant others score for psychological well-being dimension, parents' highest diploma for autonomy and parents dimension, children’s education level and home location for peers and social support dimension and the access or not to a garden for school environment. Factors associated with parental underestimation were SF12 score, home location and whether a household member was infected by COVID-19 or not for physical well-being dimension, children gender for psychological well-being dimension, presence of noise in the residence reported by children, parent’s highest diploma and family structure for autonomy and parents dimension, children’s education level for peers and social support dimension, and SF12 score and the access or not to a garden for school environment.ConclusionAgreement between child and parent reports was mostly good. However, discrepancies may occur and the directional discrepancy showed parents’ tendency to underestimate their child’s health-related quality of life. These discrepancies can be explained by living and sociodemographic factors. It will therefore be important to take these factors into account in the use of parent-estimated child health-related quality of life in future studies.