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Several moisture and temperature-sensitive medicines cannot be manufactured in Sudan due to extreme climatic conditions. Keeping these factors under control during production is difficult task. It is possible to overcome these difficulties by using excipients and utilizing technology in the production of the drug. This study aimed to adjust and improve the formulation of aspirin using different excipients and different technological approaches to produce stable aspirin tablets. Microcrystalline cellulose and lactose were used as fillers and stearic acid as a lubricant, four aspirin formulations, two formulations containing lactose and two formulations containing microcrystalline cellulose were prepared for aspirin 100 mg. For each formulation, wet granulation and direct compression techniques were applied separately, to study the effect of manufacturing technology and the role of excipients on the stability of the product. Prepared tablets were subjected to various quality control tests.  Lactose had lower moisture content than MCC. But MCC has moisture scavenger characteristic. Direct-compression CDs with MCC shows less degradation than other tablet formulations. Addition of stearic acid as a substitute for magnesium stearate (a lubricant) changes the overall pH to more acidic which reduces hydrolysis.

Hair growth is controlled by hair Follicles which show patterns of cyclic activity with periods of active growth and hair production (anagen), apoptosis-driven involution (catagen) and relative resting (telogen). These transformations are regulated by different variations like endocrine, vascular, neural, age and nutritional. Keratin biomaterial has been used in regenerative medicine owing to its in-vivo and in-vitro biocompatibility. The present study aimed at extracting keratin from wool by sulfitolysis, filtration by dialysis tube and freeze drying. Qualitative analysis of the keratin extract powder ensured the presence of cysteine, Keratin powder formulated as solution dosage form and pharmaceutically evaluated, Keratin extract was topically applied on the synchronized depilated dorsal skin of telogenic 4 mice and promoted hair growth by changing Hair growth initiation and completion time and quality of hair result, in wool keratin extract solution-treated groups hair growth initiation and completion time reduced and the hair result was hard, long, thick and healthy. Besides, that the keratin extract solution was a safe agent for topical administration, our study demonstrated that keratin extract stimulating hair growth by inducing the growth phase. The topical application of keratin extract may represent a promising biomaterial for the management and applications of hair follicle disorder.