Obesity is a chronic metabolic disorder that is raised by multiple biological and environmental factors. The objective of this study was to determine the thermogenesis potential of Egyptian Moringa oleifera against obesity disorder. Adult male Wistar albino rats (150-170g) were randomly divided into four groups (10 animals each) as follows: group (1) healthy rats fed standard diet and served as control, group (2) animals orally Moringa oleifera extractstandard diet (20%), group (3) obese rats fed high-fat diet and group (4) obese animals administrated Moringa oleifera extracthigh-fat diet (20%). After six weeks of feeding, the results revealed that feeding of obese animals on moringa (20%) mixed diet succeeded to decline the body weight as well as obesity-induced disorders; this was evidenced by the significant reduction of body weight gain and BMI values as well as levels of serum ALAT, ASAT, urea, creatinine, total cholesterol, triglycerides, LDL, LDH, CK, PON1, TNF-α and glucose. Also, cardio-hepatic MDA and nitric oxide levels ware decreased coupled with marked elevation in the levels of serum HDL and irisin as well as cardio-hepatic GSH, SOD and CAT. Moreover, the histopathological findings showed a marked regeneration. In conclusion, Moringa oleifera, as a food supplement, could play a beneficial role in management of obesity and its disorders; this could be exhibited through its bioactive components with thermogenesis mechanism and/or other multiple pathways.

Doxorubicin (DOX) is a potent available antitumor agent; however, its clinical use is limited due to its significant toxicity to most tissues and organs. Administration of DOX induced acute hepatotoxicity manifested by significant elevation in serum and liver lipid peroxidation. The present study was designed to evaluate and confirm the protective effect of Nigella sativa (N.S), Aloe vera (A.V) and their mixture. A cumulative dose (30 mg/kg i.p.) of DOX divided into 6 equal doses administered over six weeks to male albino rats separate or combined with N.S, A.V or their mixture extract. At the end of the experiment, biochemical and histological parameters were assessed. Concerning oxidative stress and antioxidant defense system, the depleted hepatic glutathione content (GSH) of DOX-administered rats as well as glutathione peroxidase (GPx), catalase (CAT) and super oxide dismutase (SOD) activities were increased above normal levels as a result of pretreatment with N.S, A.V and their mixture. However, while elevated lipid peroxidation was noticed in DOX treated rats, pretreatment with N.S, A.V and their mixture produced a detectable decrease in the lipid peroxidation level. Histological measurements showed that DOX caused a marked rise multiple focal coagulative necrosis of hepatocytes associated with hemorrhage while rats pretreated with N.S, A.V and their mixture in combination with DOX showed no histopathological changes compared to normal control. From these data, it can be concluded that N.S, A.V and their mixture of extracts could be protective for the liver cells against DOX-induced hepatotoxicity due to their contents of polyphenolic compounds that might serve as novel adjuvant therapy with DOX.

The present study aimed toevaluate the toxicity of chlorpyrifose and/or glyphosate and protective effect of vitamin C on some hematological and renal parameters in male albino rats. 110 rats were used in these study divided to 11 groups. The animals were treated orally with chlorpyrifose (7.5 and 15 mg/kg) and glyphosate (500 and 1000 mg/kg) on a daily basis for a periods of 30 and 60 days. Samples of blood and serum were collected at the end of the treatment. Alterations of hematological parameters were monitored by RBC, WBC, hemoglobin and PLTs. and renal toxicity by urea, creatinine and uric acid then estimated the electrolytes in serum (Na, K, Ca and Cl). The hematological parameters showed significant decrease in RBCs, WBCs, Hb and PLTs in all intoxicated groups. And the results also showed a significant increase in serum urea, creatinine and uric acid, K, Cl while a significant decrease was observed in serum Na and Ca level. on the other hand,these observations were ameliorated in intoxicated groups with vitamin C. In conclusion, it appears that vitamin C (as antioxidants) ameliorate the hematological and renal toxicity of Chlorpyrifose and Glyphosate or its mixture.

Background: Diabetes is one of the most important causes of mortality and morbidity all over the world. Renewal of functional pancreatic islets has been a goal of stem cell biologists since early 2000. Since that time, many studies have reported successful creation of glucose-responsive pancreatic beta-cells. Aim of work: This work aimed to study the effect of MSC.s alone and/or in combination with vitamin D 3 in Streptozotocin (STZ)induced diabetic male albino rats to detect its potential therapeutic effect and its possible application to humans. Material and methods: Twenty-four male albino rats (150-170 grams) were included in this study. They were divided into four equal groups; each group have six rats: Group I (Normal: control of healthy), group II (STZ: control of diabetes), group III (diabetic group post-treated with MSC.s) and group IV (diabetic group post-treated with MSC.sin combination with vitamin D 3). Diabetes was induced by intraperitoneal injection of STZ (50 mg/kg); MSC.s were injected intravenously into the rat tail vein in group III and group IV then left for sixweeks; vitamin D (cholecalciferol) was administered orally at 150 ng (500 IU/kg) each other day at three times per week for a long 6 weeks.Blood glucose leveland body weight were measured weekly for all groups at the beginning of the study at the intervalsixweeks. While, haematological parameters were measured after six weeks. Results: Diabetic group (group II) showed significant higher glucose levels while there was a significant lower body weight levels compared to control of non-diabetic group. Group IIIas well as group IV showed significant elevation of body weightand reduction of blood glucose level as well as amelioration of haematological parameters in compared to group II.Conclusion: treatment with MSC.sand/or in combination with vitamin D 3 showed significant lower levels of glucose and higher body weight levels as compared to diabetic group.