Background: Substance usage among youths is becoming a great problem worldwide, particularly in college and university students. Khat is one of the most frequently used substances among these groups of population. Khat chewing has serious health, social and economic consequences. However, in our setting the magnitude, pattern and factors contributing to the use of Khat is not well addressed. Therefore, this study was conducted to assess the prevalence, pattern and associated factors of Khat chewing among Debre Berhan University students in Ethiopia. Methods:This cross-sectional study was design to quantify the mastication of khat and identify socio demographic, behavioral and social factors among undergraduate students. Data was collected through structured, self-administered and pre-tested questionnaire. Stratified random sampling was used to recruit 406 students. Bivariable and multivariable logistic regression analyses were fitted via SPSS statistical software package to identify associated factors of khat chewing. Results:The life time and current prevalence of khat chewing were estimated to be 20.1% and 12.2%, respectively. Out of ever chewers, 68 (84%) were in the age group of 18-24 years and 62 (76.5%) were male. The most common reasons to chew khat were for examination preparation (41.9%) followed by socialization (38.3%). Significant association was observed between khat chewing and family members chewing khat (AOR = 6.26; 95% CI: 2.67, 14.72), friends chewing khat (AOR = 6.89; 95% CI: 3.71, 14.80) and use of alcohol (AOR = 2.50; 95% CI: 1.36, 4.60). Conclusion:The prevalence of khat chewing in this study was significantly higher when compared to some previous studies done in Addis Ababa University. The pattern of khat chewing among university students was not restricted by social regulation mechanisms, and even, it seems a social norm. Therefore, teachers in high schools, colleges and instructors in university should follow their students' substance use behavior including khat and need to counsel those students who are at risk of substance use. Moreover, families ought to be a role model for their children by avoiding risk behaviors.

Introduction: Epilepsy is chronic brain disorder characterized by recurrent derangement of the nervous system due to sudden excessive disorderly discharge of the cerebral neurons. People living with epilepsy continue to suffer from enacted or perceived stigma that is based on myths, misconceptions, and misunderstandings that have persisted for many years. Therefore, this study aimed to assess the community general knowledge and attitude towards epilepsy. Methods: Community based cross sectional study was conducted to assess public general knowledge and attitude towards epilepsy and its associated factors using structured pretested questionnaire. Data was entered into Epi data version 3.1 and transported to SPSS version 21 further analysis. Both Bivariable and Multivariable Logistic Regression was done to identify associated factors. Odds Ratios and their 95% Confidence interval was computed and variables with p value less than 0.05 was considered significantly associated factors. Results: 596 study participants were participated with a response rate of 98%. Among the study participants 43.6 (95% CI: 39.6, 47.5) had poor knowledge and 41.3 (95% CI: 37.4, 45.1) had unfavorable attitude. Being secondary education, marital status, witnessed seizure, and heard the term epilepsy were showed statistically significant association with poor knowledge about epilepsy. Level of education, low average monthly income, not witnessed seizure, not heard the term epilepsy and distant from health facility showed statically significant association with the unfavorable attitude. Conclusion: In this study, Debre Berhan communities were found to have deficits in terms of general knowledge and attitude about epilepsy; and it should be given due attention.