No abstract

the internet most commonly browse using a computer (62%), smartphone (28%), or tablet (10%). 46% of subjects use the internet daily. Subjects with diabetes were the most likely to monitor or keep track of their disease (69%), followed by COPD (49%), depression (46%), and OA (39%). Subjects with diabetes or OA were more likely than subjects with COPD or depression to use the internet to research their disease and/ or treatments and 47% of all subjects reported doing so on at least a monthly basis. Subjects across all cohorts were most likely to research information on their current treatments (77%) followed by impact of diet on disease (68%), new drugs (42%), and disease complications (41%). With respect to their general health, subjects across all cohorts were most likely to search online for food (72%) and exercise (52%) recommendations. ConClusions: The extent to which subjects with chronic disease use eClinical technology to track and research health information depends in part on which disease they have. Understanding the type of health information that patients investigate online may help identify areas for more effective intervention and use of eClinical technology. PIH46AlIgnIng PAtIent Centred evIdenCe generAtIon ACross tHe drug develoPment lIfeCyCle

Objectives: Patient engagement and adherence are critical to the success of clinical trials. Electronic patient-reported outcomes (ePROs) are increasingly used to evaluate clinical trial endpoints. This study characterized how subjects prefer to use various types of technology to report ePROs in a clinical trial. Considering patient preference during trial design may reduce patient burden and improve patient engagement. MethOds: 416 subjects with osteoarthritis (OA, n= 104), type 2 diabetes (n= 102), chronic obstructive pulmonary disease (COPD, n= 103), or depression (n= 107) were surveyed regarding their preferences for using computers, smartphones, and internet in clinical trials. Results: Subjects were diverse in age, sex, ethnicity, and technology use. 52% reported having a computer at home, 46% reported using the internet daily, and 45% reported owning a smartphone. Subjects reported that they would be willing to participate in a clinical trial using the internet for up to 1 month (25%), 2-6 months (19%), 1-2 years (14%), or 5+ years (15%). Similarly, subjects were willing to participate in a clinical trial using a smartphone for up to 1 month (25%), 2-6 months (22%), 1-2 years (12%), or 5+ years (14%). When asked what time of day they would prefer to complete a daily electronic diary, subjects preferred 8pm-midnight (26%), 8am-noon (21%), or 4pm-8pm (15%). Subjects thought it would be necessary (14%) or helpful (69%) to have an audible alarm to remind them to record their symptoms. In a multi-select question, subjects preferred to report their symptoms once a day for a clinical trial using a provisioned smartphone (49%), internet (46%), or an application on their personal smartphone (42%). cOnclusiOns: Subjects are willing to use computers, smartphones, and internet in a clinical trial setting. Trial sponsors should consider patient preferences for specific technology features to reduce patient burden and improve engagement and adherence when using ePRO assessments. PIH39develoPment and evalUatIon of a crosswalk between tHe eq-5d-5l and menoPaUse-sPecIfIc qUalIty of lIfe (menqol) qUestIonnaIre In PostmenoPaUsal women

Objectives: Patient engagement and adherence are critical to the success of clinical trials. Electronic patient-reported outcomes (ePROs) are increasingly used to evaluate clinical trial endpoints. This study characterized how subjects prefer to use various types of technology to report ePROs in a clinical trial. Considering patient preference during trial design may reduce patient burden and improve patient engagement. MethOds: 416 subjects with osteoarthritis (OA, n= 104), type 2 diabetes (n= 102), chronic obstructive pulmonary disease (COPD, n= 103), or depression (n= 107) were surveyed regarding their preferences for using computers, smartphones, and internet in clinical trials. Results: Subjects were diverse in age, sex, ethnicity, and technology use. 52% reported having a computer at home, 46% reported using the internet daily, and 45% reported owning a smartphone. Subjects reported that they would be willing to participate in a clinical trial using the internet for up to 1 month (25%), 2-6 months (19%), 1-2 years (14%), or 5+ years (15%). Similarly, subjects were willing to participate in a clinical trial using a smartphone for up to 1 month (25%), 2-6 months (22%), 1-2 years (12%), or 5+ years (14%). When asked what time of day they would prefer to complete a daily electronic diary, subjects preferred 8pm-midnight (26%), 8am-noon (21%), or 4pm-8pm (15%). Subjects thought it would be necessary (14%) or helpful (69%) to have an audible alarm to remind them to record their symptoms. In a multi-select question, subjects preferred to report their symptoms once a day for a clinical trial using a provisioned smartphone (49%), internet (46%), or an application on their personal smartphone (42%). cOnclusiOns: Subjects are willing to use computers, smartphones, and internet in a clinical trial setting. Trial sponsors should consider patient preferences for specific technology features to reduce patient burden and improve engagement and adherence when using ePRO assessments. PIH39develoPment and evalUatIon of a crosswalk between tHe eq-5d-5l and menoPaUse-sPecIfIc qUalIty of lIfe (menqol) qUestIonnaIre In PostmenoPaUsal women