Pendahuluan: Sindrom koroner akut (SKA) merupakan masalah kardiovaskular utama yang menyebabkan angka perawatan dan kematian yang tinggi. Enzim jantung seperti troponin dan Creatinin Kinase-MB (CKMB) dilepaskan ke peredaran darah dan meningkat pada infark miokard. Elektrolit adalah zat berfungsi untuk menghantarkan listrik. Aktivitas listrik jantung diatur oleh kalsium, kalium dan natrium; kontraksi jantung membutuhkan kalsium, magnesium dan fosfor. Elektrolit berguna sebagai indikator AMI. Penelitian ini bertujuan menganalisis kadar serum elektrolit dengan petanda jantung pada SKA. Metode: Penelitian belah lintang pada 35 pasien SKA pada bulan Desember - Januari 2018. Kadar elektrolit serum diperiksa dengan metode Ion selective electrode (ISE) dan photometric, kadar CKMB diperiksa dengan metode Enzyme-linked immuno assay (ELISA), kadar Troponin I (cTnI) diperiksa dengan metode Enzyme-linked fluorescence assay (ELFA). Uji Korelasi spearman digunakan untuk menganalisis data, signifikan jika p <0.05. Hasil: Terdapat korelasi negatif kuat antara natrium, kalium, clorida, dan magnesium baik dengan CKMB (p 0,000/ 0,000/ 0,001/ 0,014 dan r= -0,631/ -0,634/ -0,557/ -0,412) maupun cTnI (p 0,000/ 0,000/ 0,001/ 0,000 dan r= -0,746/ -0,574/ -0,545/ -0,564). Tidak terdapat korelasi antara kalsium baik dengan CKMB (p= 0,475 dan r= -0,125) maupun cTnI (p= 0,086 dan r= -0,294). Simpulan: Terdapat hubungan negatif antara natrium, kalium, clorida, dan magnesium dengan petanda jantung, tidak terdapat hubungan antara kalsium dengan petanda jantung pada SKA. Temuan ini menunjukkan bahwa rendahnya kadar serum elektrolit pada SKA dapat berarti adanya area infark yang lebih luas. Hasil penelitian ini perlu divalidasi dalam penelitian berskala besar dengan metodologi yang lebih baik dan diharapkan dapat menjadi dasar penelitian lebih lanjut. Kata Kunci: SKA, Elektrolit, CKMB, cTnI Introduction: Acute coronary syndrome (ACS) is a major cardiovascular problem that causes significant morbidity and mortality burden. Cardiac enzymes, such as troponin and Creatinin Kinase-MB (CKMB), are released into the bloodstream and increase in acute myocardial infarction (AMI). Electrolytes involving calcium, potassium and sodium regulate heart electrical activity, while calcium, magnesium and phosphorus regulate its contraction. Electrolytes serve as AMI indicators. This study aims to analyze serum electrolyte levels with cardiovascular markers in ACS. Methods: a coss sectional study of 35 ACS patients was conducted from December to January 2018. Serum electrolyte levels were examined by the Ion selective electrode (ISE) and photometric method, CKMB levels were examined by the enzyme-linked immuno assay (ELISA), Troponin I (cTnI) were examined by the Enzyme-linked fluorescence assay (ELFA) method. Spearman test was perfomed for analyzing data with significant level of <0.05. Results: a strong negative correlation was found between sodium, potassium, chloride, and magnesium and both CKMB (p 0,000 / 0,000 / 0,001 / 0,014 and r = -0,631 / -0,634 / -0,557 / -0,412) and cTnI (p 0,000 / 0,000 / 0.001 / 0,000 and r = -0,746 / -0,574 / -0,545 / -0,564). No correlation was found between calcium and both CKMB (p = 0.475 and r = -0.125) and cTnI (p = 0.086 and r = -0.294). Conclusion: There is significant negative correlation between sodium, potassium, chloride, and magnesium and cardiac markers, there is no correlation between calcium and cardiac markers in ACS. These findings indicate low serum electrolytes values in ACS may have higher area of infarction. These finding need to be validated in large-scale studies with better methodologies and are expected to be the basis for further research. Keywords: ACS, Electrolytes, CKMB, cTnI.
Introduction: Obesity is one of global epidemic health problems. Obesity has been suggested to be associated with a state of chronic low-grade inflammation, which is characterized by abnormal cytokine production, increased acutephase reactants and activation of inflammatory signaling pathways. NLR (neutrofil to lymphocyte ratio) a simple and reliable indicator of inflammation, have been reported to be associatied with metabolyc syndrom, insulin resitence, and obeity in more study. Ferritin is a marker of inflammation contribute in obesity, and have been reported that ferritin is a marker of inflammation rather than iron status in overweight and obese people. Relationship between anemia and obesity may be due to fat a ccumulation and chronic inflammation in adipose tissue can be decreased iron absorbtion. Methods: Cross-sectional study of 50 obesity subject, based Pendahuluan: Obesitas merupakan salah satu masalah kesehatan global. Obesitas dikaitkan dengan keadaan inflamasi kronis tingkat rendah yang ditandai oleh produksi sitokin abnormal, peningkatan protein fase akut dan aktivasi jalur sinyal inflamasi. NLR (neutrofil to lymphocyte ratio) sebagai petanda inflamasi yang mudah dan murah, terbukti berhubungan dengan sindrom metabolik, resisten insulin dan obesitas pada beberapa penelitian. Ferritin suatu petanda inflamasi dikaitkan dengan obesitas dan dikatakan bahwa ferritin merupakan petanda inflamasi daripada petanda status besi pada obesitas atau kelebihan berat badan. Obesitas berkaitan dengan anemia karena penimbunan lemak dan inflamasi kronis di jaringan adiposa dapat menurunkan penyerapan zat besi. Metode: Penelitian belah lintang pada 50 orang obesitas berdasarkan kriteria Riskesdas pada bulan Mei-September on Riskesdas criteria, on Mei-September 2018. Marker of inflammation is ferritin serum was measured by ELISA (enzyme linked immunosorbent assay), and NLR and haemoglobin was perfomed from haematology analyzer. Spearman test was perfomed for analyzing data with p <0,05 was significant Results: No correlation between NLR and haemoglobin, r= 0,067 and p= 0,642, and significant strong positive correlation between ferritin and haemoglobin, r= 0,630 and p < 0,000. Conclusion: There was no correlation between NLR and haemoglobin, and there was significant strong positive correlation between ferritin and haemoglobin in obesity. Future research need to observe with evaluate hepcidin, other iron status parameter and marker of inflammation. 2018. Petanda inflamasi adalah ferritin serum diperiksa dengan metode ELISA (enzyme linked immunosorbent assay) dan NLR dan hemoglobin diperiksa menggunakan haematology analyzer. Uji Korelasi spearman digunakan untuk menganalisis data, signifikan jika p <0,05. Hasil: Tidak terdapat korelasi antara NLR dengan Hemoglobin, r= 0,067 dan p= 0,642, dan terdapat korelasi positif kuat antara ferritin dengan hemoglobin, r= 0,630 dan p < 0,000. Simpulan: Tidak terdapat hubungan antara NLR dengan hemoglobin, dan terdapat hubungan positif kuat antara ferritin dan hemoglobin pada obesitas...
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