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This chapter introduces a standards-based and adaptive framework whose main objective is to adapt user interfaces, content and learning environment to learners’ needs, including their functional diversity issues (i.e., disabilities). The framework is intended to be general (e.g., two different learning management systems and two large pilot sites are being considered) and to that end it is implemented in terms of an open architecture, which aims at providing services for Accessible Lifelong Learning. The chapter focuses on accessibility and adaptation issues, and their interoperability requirements. The covered topics are the required standards, interoperability requirements of the architecture, user model, recommender system, and their application to the end-user services that are being implemented at UNED University, one of the large pilot sites of the EU4ALL European project. Some of the challenges and solutions provided are discussed as well as the future work of related research areas.

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