This study illustrates the effects of national culture on tourists' destination choices to Asian and the Middle East. This study clarifies how national cultural configurations indicate international tourists' willingness‐to‐travel to destinations. Five countries in this region—India, Iran, China, Egypt, and Jordan—were selected as destinations of outbound tourism in world counties. Fuzzy qualitative comparative analysis approach was applied to consider how complex configurations of national culture affect international tourism in countries mentioned. The study examines 6 attributes/conditions to explain outcomes. Results demonstrated that configurations that more important in selection Asian and Middle East destinations are presences of happiness and absences of cultural distance, dynamic externality, and societal cynicism. This study supports the cultural values and the cultural distance between origins and destinations, one of the antecedents of tourists' behaviours.