The Brazelton Neonatal Assessment Scale was administered to 52 newborn infants. A factor analysis revealed 2 main factors, 1 along an attention-orientation dimension, the other relating to temperament arousal. A stepwise multiple linear regression analysis showed that the attention-orientation factor was related to birth weight, age of the mother, and sex and race of the baby. The only variable related to the temperament-arousal factor was 5-min Apgar scor. The study, although exploratory, demonstrates the use of multivariate techniques in the assessment of influences on newborn behavior.

A radioimmunoassay (RIA) was developed for the quantification of caffeine in saliva. The mean salivary caffeine level for this sample of 40 full-term, AGA, healthy 1-2 day old human neonates was consistent with levels reported in previous studies. Salivary caffeine was significantly correlated with the number of state changes and startles observed during administration of the Brazelton Neonatal Behavior Assessment Scale. There was also a nonsignificant trend correlating salivary caffeine with visual orienting and consolability.

Neurobehavioral evaluation of the high-risk neonate represents an important advance in early detection of behavioral anomalies which may give rise to later neuropsychological sequelae. In the present study neonates comprising three diagnostic categories (i.e., respiratory distressed, seizure-disordered, normals) were evaluated with the Brazelton Neonatal Behavior Assessment Scale (BNBAS) to determine the extent to which differences in neurobehavioral organization could be detected with the scale, and how they were related to diagnostic classification. Average conceptional age at testing for the three groups was within the range usually considered full term: e.g., 38.81 weeks (respiratory distressed), 40.18 weeks (normal healthy) and 42.54 weeks (seizure disorder). Infants who had been diagnosed with neonatal seizures exhibited consistently less optimal behavior than did either of the other two groups. Infants with respiratory distress and normal controls did not differ significantly on most summary measures of neurobehavioral organization scored with the BNBAS. The study offers support for the discriminative validity of the BNBAS and its potential usefulness in the assessment of clinically ill newborns.