A radioimmunoassay (RIA) was developed for the quantification of caffeine in saliva. The mean salivary caffeine level for this sample of 40 full-term, AGA, healthy 1-2 day old human neonates was consistent with levels reported in previous studies. Salivary caffeine was significantly correlated with the number of state changes and startles observed during administration of the Brazelton Neonatal Behavior Assessment Scale. There was also a nonsignificant trend correlating salivary caffeine with visual orienting and consolability.

Neurobehavioral evaluation of the high-risk neonate represents an important advance in early detection of behavioral anomalies which may give rise to later neuropsychological sequelae. In the present study neonates comprising three diagnostic categories (i.e., respiratory distressed, seizure-disordered, normals) were evaluated with the Brazelton Neonatal Behavior Assessment Scale (BNBAS) to determine the extent to which differences in neurobehavioral organization could be detected with the scale, and how they were related to diagnostic classification. Average conceptional age at testing for the three groups was within the range usually considered full term: e.g., 38.81 weeks (respiratory distressed), 40.18 weeks (normal healthy) and 42.54 weeks (seizure disorder). Infants who had been diagnosed with neonatal seizures exhibited consistently less optimal behavior than did either of the other two groups. Infants with respiratory distress and normal controls did not differ significantly on most summary measures of neurobehavioral organization scored with the BNBAS. The study offers support for the discriminative validity of the BNBAS and its potential usefulness in the assessment of clinically ill newborns.

Brainstem Evoked Response Audiometry (BERA), being the most sensitive and specific test of hearing assessment in new-borns is beneficial for early detection of hearing impairment in high risk infants. BACKGROUND AND OBJECTIVEBERA was recorded in all high risk infants as defined by JCIH, 2007 criteria for identification of hearing deficits and to identif y severity of hearing loss.

Purpose – The prevalence of diabetes has increased manifold and now become a public health problem from being mild disorder. There is a need to discover more effective and safer antidiabetic agents by utilizing the rich heritage of medicinal plants. Tannins are polyphenols that are obtained from various parts of different plants belonging to multiple species and considered as potential drugs for the treatment of non-insulin-dependent diabetes mellitus. The paper aims to discuss these issues. Design/methodology/approach – The study was conducted in three phases: incorporation of Babul powder in biscuits: assessment of Glycemic Index (GI): suitability of Babul powder on diabetic subjects statistical analysis: area under curve (AUC) for increase in blood glucose was calculated by trapezoidal rule and means were tested for significance by paired t-test. Mean glucose levels of all subjects were calculated for each time point. p<0.05 was considered statistically significant. Findings – Tannins are polyphenols that are obtained from various parts of different plants belonging to multiple species. As an indigenous plant of Rajasthan, Babul contains high amount of tannin levels ranging from 18 to 27 percent in deseeded pods from ssp. indica, whereas ssp. nilotica reached up to 50 percent. Hence, Babul was selected as the source of tannin and subjected to diabetics for its suitability. The study concluded that Babul powder is effective in management of blood glucose levels even the simple sugars also and can be considered as suitable for diabetics. The active component for the purpose may be the presence of tannin in the Babul. Research limitations/implications – The study was conducted on limited number of subjects. A confirmation study is suggested on the diabetic population. Originality/value – The prevalence of diabetes is rapidly rising all over the globe at an alarming rate. Over few decades, the status of diabetes has changed from being considered as a mild disorder of the elderly to one of the major causes of morbidity and mortality affecting the youth and middle-aged people. Therefore, the present study focused on the development of tannin-based nutraceutical for incorporation in common foods and its health-promoting effect on diabetes.

No abstract