In the presence of triphenylphosphine, copper (II) chloride can catalyze an intermolecular ortho-acylation reaction of phenols with aryl aldehydes. The reaction proceeds smoothly with a wide range of starting materials, and furthermore, it can be used to synthesize xanthone derivatives in a single step with high-yields.
This paper presents a graphene nanosensor for affinity-based detection of low-charge, low-molecular-weight molecules, using glucose as a representative. The sensor is capable of measuring glucose concentration in a practically relevant range of 2 μM to 25 mM, and can potentially be used in noninvasive glucose monitoring.
Modification of an enveloped measles virus was achieved by metabolic incorporation of azido sugars in host cells through the protein glycosylation process. Based on this, the resulting measles virus particles could be modified with azido groups on the surface glycoproteins, which could be further labeled with fluorescence dyes using a strain-promoted azide-alkyne cycloaddition reaction. We envision this metabolic labeling approach to be applicable to a wide variety of enveloped viruses, allowing the facile conjugation and surface modification.
The successful modification of enveloped virus with polymeric imidazole ligand coated quantum dots was achieved by metabolic labeling and the click reaction.
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