A graphene-based affinity nanosensor for detection of low-charge and low-molecular-weight molecules

Zhu, Yibo; Hao, Yufeng; Adogla, Enoch A.; Yan, Jing; Li, Dachao; Xu, Kexin; Wang, Qian; Hone, James; Lin, Qiao

doi:10.1039/c5nr08866f

Cited by 59 publications

(33 citation statements)

References 34 publications

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“…[12] The broad sensing potential of graphene can only be unlocked by the introduction of sensitizer (bio)molecules and structures, e.g. various inorganic groups, [23][24][25][81][82][83][84][85][86][87][88][89][90] organic or organometallic molecules, [37,[91][92][93][94][95][96] DNAs, [97][98][99][100][101] proteins, [102] peptides, [30,31,103,104] nanoparticles, [105,106,107] and 2D heterostructure. [51,52,61,108] These molecules are able to respond chemically or physically to their nearby environment, whose responses could then be transduced into an appreciable change in the conductivity of the carbon-based honeycomb scaffold.…”

Section: Meeting the Challenges In Chemical Functionalization Of Grapmentioning

confidence: 99%

Sensing at the Surface of Graphene Field‐Effect Transistors

et al. 2016

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Abstract. 10Recent research trends now offer new opportunities for developing the next generations of label-free biochemical sensors using graphene and other two-dimensional materials. While the physics of graphene transistors operated in electrolyte is well grounded, important chemical challenges still remain to be addressed, namely the impact of the chemical functionalizations of graphene on the key electrical parameters and the sensing performances. In fact, graphene -at least ideal graphene -is highly chemically inert. The 15 functionalizations and chemical alterations of the graphene surface -both covalently and non-covalently -are crucial steps that define the sensitivity of graphene. The presence, reactivity, adsorption of gas and ions, proteins, DNA, cells and tissues on graphene have been successfully monitored with graphene. This review aims to unify most of the work done so far on biochemical sensing at the surface of a (chemically functionalized) graphene field-effect transistor and the challenges that lie ahead. We are convinced that graphene biochemical sensors 20 hold great promises to meet the ever-increasing demand for sensitivity, especially looking at the recent progresses suggesting that the obstacle of Debye screening can be overcome.2

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Section: Meeting the Challenges In Chemical Functionalization Of Grapmentioning

confidence: 99%

Sensing at the Surface of Graphene Field‐Effect Transistors

et al. 2016

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“…All these weaknesses limit its application. Graphene is a twodimensional (2D) nanomaterial which is widely used in sensors 11 and transparent conductive lm. 12 Because of its low cost and light weight, graphene is deemed as another promising material for exible electrothermal heaters.…”

mentioning

confidence: 99%

High-performance graphene-based flexible heater for wearable applications

Lin

Zhang

et al. 2017

RSC Adv.

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In this paper, a high-performance large-scale flexible heater based on graphene and silver particles is described. The graphene-based heater can be integrated into various systems without having to be too selective about the substrate used. When silver particles are mixed with graphene, the sheet resistance is greatly reduced to 158.7 U sq the advantages of a low driving voltage, high steady-state temperature, ultrafast response and excellent flexibility, the graphene-based heater is expected to be a promising potential candidate for various wearable heating applications.

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“…The D band is due to the out-ofplane breathing mode of the sp 2 atoms and is related to the structural defects [21]. Raman spectra record the functionalization step of graphene as shown in Figure 2 can be assigned to the introduction of disorder arising from orbital hybridization of the molecule with the graphene plane, and the bands at 1611.3 cm −1 are due to the pyrene group resonance [22]. After the probe DNA was further immobilized on the graphene/PBASE layer, more bands appeared at 1476.4, 1502.5, and 1655.8 cm −1 which can be assigned to the vibrational modes of DNA molecules [23].…”

Section: Resultsmentioning

confidence: 99%

RNA Detection Based on Graphene Field-Effect Transistor Biosensor

Tian

Zhang

et al. 2018

Advances in Condensed Matter Physics

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Graphene has attracted much attention in biosensing applications due to its unique properties. In this paper, the monolayer graphene was grown by chemical vapor deposition (CVD) method. Using the graphene as the electric channel, we have fabricated a graphene field-effect transistor (G-FET) biosensor that can be used for label-free detection of RNA. Compared with conventional method, the G-FET RNA biosensor can be run in low cost, be time-saving, and be miniaturized for RNA measurement. The sensors show high performance and achieve the RNA detection sensitivity as low as 0.1 fM, which is two orders of magnitude lower than the previously reports. Moreover, the G-FET biosensor can readily distinguish target RNA from noncomplementary RNA, showing high selectivity for RNA detection. The developed G-FET RNA biosensor with high sensitivity, fast analysis speed, and simple operation may provide a new feasible direction for RNA research and biosensing.

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A graphene-based affinity nanosensor for detection of low-charge and low-molecular-weight molecules

Cited by 59 publications

References 34 publications

Sensing at the Surface of Graphene Field‐Effect Transistors

Sensing at the Surface of Graphene Field‐Effect Transistors

High-performance graphene-based flexible heater for wearable applications

RNA Detection Based on Graphene Field-Effect Transistor Biosensor

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