Soil sickness of ginseng (Panax ginseng C. A. Mey.) has become a major limiting factor in ginseng cultivation. We found that Total Ginsenoside in Ginseng Root (TSPG) significantly decreased the activities of soil urease, acid phosphatase and laccase. Its high concentration of TSPG (10.00 mg L-1) significantly reduced the activity of soil sucrose. Besides, the TSPG can inhibited the growth of ginseng and increased the incidence of disease. Therefore, allelopathic effects of TSPG may be one of the main causes of Soil Sickness in ginseng.

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