AimObesity tracks from childhood into adulthood. We evaluated the effect of early stimulation of physical activity on growth, body composition, motor activity and motor development in toddlers.MethodsWe performed a cluster randomised controlled single‐blinded trial in Dutch Well Baby Clinics, with seven nurses and 96 children (40% girls) randomised to the intervention group and six nurses and 65 children (57% girls) to the control group. Intervention nurses advised parents on stimulating motor development and physical activity during regular visits at 2 weeks and two, four, eight and 11 months. Baseline characteristics such as birthweight and mode of feeding were comparable. Outcomes at two‐and‐a‐half years included anthropometry, skinfold thicknesses, bioelectrical impedance analyses, motor development and daily physical activity. We used linear mixed models with nurses as cluster.ResultsWe evaluated 143 children (89 intervention, 54 control) as 18 dropped out. Skinfolds were significantly lower in intervention children (29.6 ± 4.7 mm) than controls (32.4 ± 6.0 mm), without differences in motor development or daily physical activity. Female interventions showed lower weight, skinfolds, waist and hip circumference.ConclusionAn activity stimulating programme during the child's first year improved indicators of adiposity when they were toddlers, especially in girls. Further research should determine whether these effects persist.

No abstract

This commentary is on the original article by Faebo Larsen et al. on pages 1016-1022 of this issue.Faebo Larsen et al.1 investigate the early life determinants for developmental coordination disorder (DCD) in 7-yearold children, using data from the Danish National Birth Cohort. They explore interesting associations between (amongst others) sex, gestational age, being small for gestational age (SGA), walking attainment, and the outcome variable, DCD, respectively, reaffirming previously established DCD-determinants and adding a new one (SGA) in the process. Their main contributions are the sex-specific associations for SGA.As such, the authors' approach fits a long-standing research tradition where cautiousness regarding causal inferences prevails and research slowly and carefully progresses in understanding. We would like to take this opportunity to point out some possibilities for formulating and expanding their results using causal graphs, since recent developments in statistical perspectives on causal inference have proven the former credo 'correlation is not causation' to be overly restrictive.2 As researching pointed out previously in DMCN, causal graphs and their theory could also be of great use in the epidemiology of developmental disabilities in children. 3 Causal graphs and their associated theory have bridged the gap between statistical associations and causal connections mathematically, providing ways to test statistically (parts of) hypothetical causal models using observational data. 4 When done with appropriate caution and obeying model assumptions -albeit no more than should be customary when applying any statistical tool -this can avoid the risk of over-extrapolating the available data.Respecting constraints imposed by time and logic, the graph in Figure 1 represents one of the plausible causal mechanisms underlying the variables and as such it may form an indispensable addition to the research questions posed by Faebo Larsen et al. The arrows depict hypothesized causal effects between the variables in the model. 4 The causal hypothesis as depicted by this graph could then be evaluated with appropriate statistical tools (e.g. structural equation modelling or even logistic regression). Additionally, focussing on one specific effect, the graph and the associated theory can be used to identify those variables for which conditioning in the analysis is needed in order to obtain unconfounded effect estimates. 2,4For example, to examine the existence of a direct effect of being SGA on DCD (the dotted arrow in the graph), it can be concluded that conditioning on the variables sex, walking attainment, gestational age, and maternal background variables in the analysis would provide the correct estimate of just that effect. This would be found as the (unreported) regression coefficient of SGA on DCD in the logistic regression model of the second column of Table IV in the Faebo Larsen paper. Similar conclusions could be drawn for other (total, direct, or indirect) effects. If the total effect of being SGA ...