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Objective. Urotensin II is a potent vasoactive peptide that has been implicated in the pathophysiology of many diseases. There is no study reporting the role and level of this peptide in recipients of kidney transplant. So we aimed to study the plasma levels of urotensin II in this group of patients.Methods. Plasma urotensin II levels were analyzed in 110 subjects, who were divided into three groups: group 1 (35 kidney transplant recipients), group 2 (36 patients with chronic kidney disease), and group 3 (39 healthy controls).Results. Analysis of logarithmic transformation of urotensin II, i.e. log (urotensin II × 1000) levels, with a one-way analysis of variance yielded a P value of 0.001. Post-hoc analysis showed significantly higher log (urotensin II × 1000) levels in group 1 than groups 2 and 3 (P = 0.001 and 0.017, respectively). One of the important features of the subjects of this group was that they were taking immunosuppressive drugs because of renal transplantation.Conclusions. High urotensin II levels in recipients of kidney transplants could be drug-related (immunosuppressive drugs) and may be of practical importance that may be used to improve the long-term outcome of the patients.

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Childhood obesity is one of the most important children's health problems that is gradually increasing all over the world. Dyslipidemia which coexists with obesity is a risk factor for atherosclerotic diseases in adulthood. In this study, the usability of the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) in predicting dyslipidemia, a serious complication of obesity, in children were investigated. Method: Two hundred and seven cases aged between 11-17 years who were diagnosed with obesity at the Pediatrics Clinic of our hospital and 50 cases with no disorders whose complete blood count was performed for routine purposes were retrospectively investigated. The genders, ages, and examination findings of the cases were recorded. In obese children, leukocyte, hemoglobin, platelet, mean platelet volume, neutrophil and lymphocyte levels were evaluated in the complete blood count performed at the first admission. The NLR and the PLR were calculated. Preprandial blood glucose and preprandial insulin, serum aminotransferase values, and the lipid profile were recorded. Results: While dyslipidemia was determined in 99 (47.82%) of 207 cases who were diagnosed with obesity, it was not determined in 108 (52.18%) cases. The systolic blood pressure, diastolic blood pressure, and preprandial insulin level were higher in cases with dyslipidemia than the group without dyslipidemia. The PLR average of the dyslipidemic group was 112.75±39.11, the PLR average of the non-dyslipidemic group was 104.78±31.38, and the PLR average of the control group was 110.20±39.35, and there was no statistically significant difference between the PLR averages of the groups (p=0.353). The NLR average was 1.52±0.69 in Amaç: Çocukluk çağı obezitesi tüm dünyada giderek artan en önemli çocuk sağlığı sorunlarından biridir. Obezite ile birlikte olan dislipidemi, erişkin dönemde aterosklerotik hastalıklar için bir risk faktörüdür. Bu çalışmada çocuklarda, obezitenin ciddi bir komplikasyonu olan dislipidemiyi öngörmede nötrofil-lenfosit oranı (NLO) ve platelet-lenfosit oranının (PLO) kullanılabilirliğini araştırdık. Yöntem: Hastanemiz Çocuk Sağlığı ve Hastalıkları Kliniği'nde obezite tanısı alan 11-17 yaş arası 207 olgu ve herhangi bir rahatsızlığı olmayıp rutin amaçlı tam kan tahlili yapılan 50 olgu retrospektif olarak incelendi. Olguların cinsiyetleri, yaşları, muayene bulguları kaydedildi. Obez çocuklarda ilk başvuruda alınan tam kan sayımında lökosit, hemoglobin, trombosit, ortalama trombosit hacmi, nötrofil ve lenfosit düzeyleri değerlendirildi. NLO ve PLO hesaplandı. Açlık kan şekeri ve açlık insülin, serum aminotransferaz değerleri ve lipid profili kaydedildi. Bulgular: Obezite tanısı alan 207 olgunun 99'unda (%47,82) dislipidemi saptanırken, 108 olguda (%52, 18) dislipidemi saptanmadı. Dislipidemi saptanan olguların sistolik kan basıncı, diastolik kan basıncı ve açlık insülin düzeyi dislipidemi olmayan gruptan daha yüksekti. Dislipidemik grubun PLO ortalaması 112,75±39, 11, dispidemik olmayan grubun PLO ortalaması 104,78±31,38,...