Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) have been introduced as a possible therapy in hypoxic-ischemic encephalopathy (HIE). We report a 16-year-old boy who was treated with WJ-MSCs in the course of HIE due to post-cardiopulmonary resuscitation. He received a long period of mechanical ventilation and tracheostomy with spastic quadriparesis. He underwent the intrathecal (1×106/kg in 3 mL), intramuscular (1×106/kg in 20 mL) and intravenous (1×106/kg in 30 mL) administrations of WJ-MSCs for each application route (twice a month for 2 months). After stem cell infusions, progressive improvements were shown in his neurological examination, neuroradiological, and neurophysiological findings. To our best knowledge, this is a pioneer project to clinically study the neural repair effect of WJ-MSCs in a patient with HIE.

Aim: In this study, we aimed to analyze the properties of drained subdural fluid and post-operative follow-up of patients with chronic subdural hematoma subdivided randomly into two groups according to presence or absence of dexamethasone treatment. Material and Methods: 42 patients with chronic subdural hematoma were involved in this study. The patients were divided into two groups according to dexamethasone treatment. 21 of the patients were treated with dexamethasone. All patients underwent burr hole craniotomy and a closed system drainage was constructed. The amount and properties of per-operative versus post-operative drained subdural fluid (hemoglobin, total protein and albumin levels) were analyzed. Cranial computerized tomography scans were used for follow-up and presence of fluid collection in subdural space was controlled. Results: When compared to per-operative laboratory results, statistically significant decrease was observed in both groups. However, the decrease in dexamethasone group was more significant compared to none-dexamethasone group. Follow-up computerized tomography results showed rare new subdural fluid collection development in dexamethasone group. Conclusion: As a result, Our findings suggest that surgery with dexamethasone treatment in chronic subdural hematoma patients has a more favourable clinic result compared to surgery without dexamethasone treatment.

Background: The aim of this study was to evaluate the correlation between serum superoxide dismutase (SOD) enzyme levels and lumbar degenerative spinal diseases (LDSD).Materials and Methods: Ninety-four patients with LDSD and 64 patients without LDSD were investigated. Human SOD ELISA kits were used to measure the amount of enzymes in the samples. Serum SOD enzyme levels were determined by Student-t and Mann Whitney-U tests to determine differences between groups.Results: The patient group was classified according to the characteristics of the disease, clinical symptoms, Visual Analog Scale (VAS) values, and Oswestry Disability Index (ODI) scores. Along with these parameters, serum SOD levels were evaluated statistically. There was no statistically significant difference in serum SOD levels in both groups. However, serum SOD levels were relatively lower in the patient group (p>0.05).Conclusions: Our study could supply objective value for future researchers investigating specific lumbar diseases, should they attempt to find a serum biomarker for the disease. More studies with an increasing number of patients are needed to support the results of our study. Doing so may offer more specific insights on the mechanisms of LDSD and its features, which could contribute to the literature.

Creating a common language allows information to be shared well/wholesome/healthily. Classifications have a important role in the formation of this language, which provides many benefits such as follow-up of the clinical course. Classifications in spinal cord injuries are based on examination, so the results of different treatments can be revealed more clearly with a standardized examination and registration. The International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) which is the most sensitive and common classification was developed by the American Spinal Injury Association (ASIA) and the International Spinal Cord Society (ISCoS), although its foundations were laid in 1969 by Frankel. Apart from neurological evaluation, there are scales such as Functional Independence Scale, Modified Barthel Index, Spinal Cord Independence Scale, Quadriplegia Functional Index, Walking Index for Spinal Cord Injury, Spinal Cord Injury Functional Ambulation Inventory to determine the functional status in spinal cord injuries. Additionally scales such as Assessment of Spinal Cord Injury Basic Pain Data Set, Multidimensional Pain Inventory, DN4 (DouleurNeuropathique DN4) can be used for pain assessment in a patient with spinal cord injury.