Aim: In this study, we aimed to analyze the properties of drained subdural fluid and post-operative follow-up of patients with chronic subdural hematoma subdivided randomly into two groups according to presence or absence of dexamethasone treatment. Material and Methods: 42 patients with chronic subdural hematoma were involved in this study. The patients were divided into two groups according to dexamethasone treatment. 21 of the patients were treated with dexamethasone. All patients underwent burr hole craniotomy and a closed system drainage was constructed. The amount and properties of per-operative versus post-operative drained subdural fluid (hemoglobin, total protein and albumin levels) were analyzed. Cranial computerized tomography scans were used for follow-up and presence of fluid collection in subdural space was controlled. Results: When compared to per-operative laboratory results, statistically significant decrease was observed in both groups. However, the decrease in dexamethasone group was more significant compared to none-dexamethasone group. Follow-up computerized tomography results showed rare new subdural fluid collection development in dexamethasone group. Conclusion: As a result, Our findings suggest that surgery with dexamethasone treatment in chronic subdural hematoma patients has a more favourable clinic result compared to surgery without dexamethasone treatment.
Background: The aim of this study was to evaluate the correlation between serum superoxide dismutase (SOD) enzyme levels and lumbar degenerative spinal diseases (LDSD).Materials and Methods: Ninety-four patients with LDSD and 64 patients without LDSD were investigated. Human SOD ELISA kits were used to measure the amount of enzymes in the samples. Serum SOD enzyme levels were determined by Student-t and Mann Whitney-U tests to determine differences between groups.Results: The patient group was classified according to the characteristics of the disease, clinical symptoms, Visual Analog Scale (VAS) values, and Oswestry Disability Index (ODI) scores. Along with these parameters, serum SOD levels were evaluated statistically. There was no statistically significant difference in serum SOD levels in both groups. However, serum SOD levels were relatively lower in the patient group (p>0.05).Conclusions: Our study could supply objective value for future researchers investigating specific lumbar diseases, should they attempt to find a serum biomarker for the disease. More studies with an increasing number of patients are needed to support the results of our study. Doing so may offer more specific insights on the mechanisms of LDSD and its features, which could contribute to the literature.
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