Self-adhesive resin cements demonstrated superior bond strength to a variety of prosthodontic substrates relative to resin-modified glass ionomer cement, indicating that they are able to provide a wider array of clinical applications. However, selection of the cement should be determined largely by the type of substrate and setting reaction. SUMMARYObjective: To evaluate the shear bond strength (SBS) of three self-adhesive resin cements and a resin-modified glass ionomer cement (RMGIC) to different prosthodontic substrates.Materials and Methods: The substrates base metal, noble metal, zirconia, ceramic, and resin composite were used for bonding with different cements (n=12). Specimens were placed in a bonding jig, which was filled with one of four cements (RelyX Unicem, Multilink Automix, Maxcem Elite, and FujiCEM Automix). Both light-polymerizing (LP) and selfpolymerizing (SP) setting reactions were tested. Shear bond strength was measured at 15 minutes and 24 hours in a testing device at a test speed of 1 mm/min and expressed in MPa. A Student t-test and a one-way analysis of variance (ANOVA) were used to evaluate differences between setting reactions, between testing times, and among cements irrespective of other factors. Generalized linear regression model and Tukey tests were used for multifactorial analysis.