Measurement of muscle strength and activity of upper limbs of non-ambulant patients with neuromuscular diseases is a major challenge. ActiMyo® is an innovative device that uses magneto-inertial sensors to record angular velocities and linear accelerations that can be used over long periods of time in the home environment. The device was designed to insure long-term stability and good signal to noise ratio, even for very weak movements. In order to determine relevant and pertinent clinical variables with potential for use as outcome measures in clinical trials or to guide therapy decisions, we performed a pilot study in non-ambulant neuromuscular patients. We report here data from seven Duchenne Muscular Dystrophy (DMD) patients (mean age 18.5 ± 5.5 years) collected in a clinical setting. Patients were assessed while wearing the device during performance of validated tasks (MoviPlate, Box and Block test and Minnesota test) and tasks mimicking daily living. The ActiMyo® sensors were placed on the wrists during all the tests. Software designed for use with the device computed several variables to qualify and quantify muscular activity in the non-ambulant subjects. Four variables representative of upper limb activity were studied: the rotation rate, the ratio of the vertical component in the overall acceleration, the hand elevation rate, and an estimate of the power of the upper limb. The correlations between clinical data and physical activity and the ActiMyo® movement parameters were analyzed. The mean of the rotation rate and mean of the elevation rate appeared promising since these variables had the best reliability scores and correlations with task scores. Parameters could be computed even in a patient with a Brooke functional score of 6. The variables chosen are good candidates as potential outcome measures in non-ambulant patients with Duchenne Muscular Dystrophy and use of the ActiMyo® is currently being explored in home environment.Trial Registration: ClinicalTrials.gov NCT01611597

Abstract-We address the problem of three-axis sensor calibration. Our focus is on magnetometers. Usual errors (misalignment, non-orthogonality, scale factors, biases) are accounted for. We consider a method where no specific calibration hardware is required. We solely use the fact that the norm of the sensed field must remain constant irrespective of the sensors orientation. The proposed algorithm is iterative. Its convergence is studied. Experiments conducted with MEMS sensors (magnetometers) stress the relevance of the approach.

Abstract-We address the problem of estimating the position of a rigid body moving indoors. Disturbances of the magnetic field observed in buildings are used to derive a reliable velocity estimate. The estimated velocity is expressed in the body reference frame, which imposes to simultaneously reconstruct the rotation of this frame with respect to an inertial frame of reference. For this, an inertial measurement unit (IMU) is used. To maximize the accuracy of the reconstructed motion, alignment and calibration of the inertial sensors have to be carefully treated, which minimizes projection errors. A first contribution of this paper is an alignment-calibration technique combining gyrometers and accelerometers to address the attitude estimation problem. A second contribution is an observer of the velocity, the convergence of which is proved. Finally, an experimental testbench is described and experimental results are provided.

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This article presents an overview of fifty-eight articles dedicated to the evaluation of physical activity in free-living conditions using wearable motion sensors. This review provides a comprehensive summary of the technical aspects linked to sensors (types, number, body positions, and technical characteristics) as well as a deep discussion on the protocols implemented in free-living conditions (environment, duration, instructions, activities, and annotation). Finally, it presents a description and a comparison of the main algorithms and processing tools used for assessing physical activity from raw signals.