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Objective In this study, we aimed to evaluate the diagnostic sensitivities of 68 Ga-FAPI-04 PET/CT and 18 F-FDG PET/CT in the primary tumor, and nodal, peritoneal and distant organ metastases of primary and recurrent gastric adenocarcinoma (GAc) with patient and lesionbased comparison. Materials and methodTwenty-one patients with histopathologically proven newly diagnosed or recurrent GAc who underwent 18 F-FDG and 68 Ga-FAPI-04 imaging were included in the study. Both imaging techniques were evaluated visually according to the intensity of organbased uptake. SUVmax and tumor-to-background ratio (TBR) values obtained from primary tumor/relapse and metastatic organs were compared statistically.Results 68 Ga-FAPI-04 uptake was positive in all 15 newly diagnosed patients, while two patients among them who had mucinous and signet ring cell carcinoma did not exhibit 18 F-FDG uptake. The sensitivity and specificity of 68 Ga-FAPI-04 PET/CT in detecting primary gastric were 100%, while the sensitivity and specificity of 18 F-FDG were 86.6 and 100%, respectively. 68 Ga-FAPI-04 imaging revealed diffuse stomach uptake in seven patients, while 18 F-FDG could only show two of them. The sensitivity and specificity of in-patient-based detection of lymph node metastases were 100 and 95.2%, respectively, while these values were 71.4 and 93.7%, respectively, for 18 F-FDG. For peritoneal involvement 68 Ga-FAPI-04 had a sensitivity and specificity of 100%, whereas 18 F-FDG had a sensitivity of 40% and a specificity of 100%.Conclusion 68 Ga-FAPI-04 PET/CT is an imaging modality with the potential of yielding more sensitive and specific findings 18 F-FDG PET/CT. This modality may help avoid invasive diagnostic procedures that may be frequently required in GAc.

Purpose Pandemics can be associated with anxiety and depression in cancer patients who are undergoing treatment. In the present study, we aimed to perform a comparative evaluation of the conditions of cancer patients before and during the severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) pandemic using the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) to detect the impact of the pandemic on treatment delays that are associated with anxiety and depression in cancer patients. In addition, the effect of public transport use on treatment delays was examined. Methods BDI and BAI were administered to 595 breast, ovarian, colon and gastric cancer patients before and during the pandemic. The questionnaires were administered by the physician blindly, who was unaware of the delay of the patients. The number of days by which the patients delayed their treatment due to the fear of contamination were recorded retrospectively. Correlation analyses were performed between the obtained scores and treatment delays. Results The depression and anxiety levels in cancer patients were found to increase during the pandemic (p = 0.000), and this increase was positively correlated with the disruption of their treatment (p = 0.000, r = 0.81). Depression and anxiety levels and treatment delays were higher in elderly patients (p = 0.021). Depression and anxiety were more pronounced in female patients (p = 0.000). Moreover, treatment delays were more common in patients who had to use public transportation (p = 0.038). Conclusion SARS-CoV-2 pandemic may increase anxiety and depression in cancer patients. This can cause patients to experience treatment delays due to concerns about becoming infected. At this point, if necessary, assistance should be obtained from psychiatric and public health experts.

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