The purpose of this study is to explore the measurement of human factors in the workplace that can provide critical insights into workers' well-being. Human factors refer to physical, cognitive, and psychological states that can impact the efficiency, effectiveness, and mental health of workers. The article identifies six human factors that are particularly crucial in today's workplaces: physical fatigue, attention, mental workload, stress, trust, and emotional state. Each of these factors alters the human physiological response in a unique way, affecting the human brain, cardiovascular, electrodermal, muscular, respiratory, and ocular reactions. This paper provides an overview of these human factors and their specific influence on psycho-physiological responses, along with suitable technologies to measure them in working environments and the currently available commercial solutions to do so. By understanding the importance of these human factors, employers can make informed decisions to create a better work environment that leads to improved worker well-being and productivity.INDEX TERMS Human factors, industry 5.0, psycho-physiological signals, human physical and cognitive states, signal acquisition, measuring techniques, human-in-the-loop, industrial applications.

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