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Asymmetrical foamy-celled change in the right lobe of the liver in newborn infants was noted by Gruenwald (1949), and we have described (Emery, 1952) Schiff (1953) estimated the liver lipids in man in different parts of the liver by means of specimens taken by needle biopsy. They also found relative uniformity throughout the liver and that the histology and chemical estimation of fat content paralleled each other. Most of these investigations, however, were done on livers from adults.This communication records an attempt to establish the normal fat and water contents of the left and right livers in later foetal and early neonatal life.Materials and Methods For about a year the fat and water content of the left and right liver has been estimated on all (134) stillborn and neonatal infants coming to necropsy. The livers were divided into three parts by two cuts, one along the line of the anterior ligament and ductus venosus, that is, cutting off the anatomical left lobe. The second cut was taken from the tip of the gall bladder to the inferior vena cava through the base of the gall bladder to the hilum. This cut divides the liver into the physiological left and right lobes. The central part of the liver constituting the median part of the left physiological lobe was discarded after weighing. Blocks of distinctive shape were taken for histology from the left and right lobes, the remainder of which were then separately cut into thin slices by a very sharp knife and blotted to remove as much blood as possible.

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