Background: In IDDM, diabetic nephropathy is the major life threatening complication, including microalbuminuria and steady decline in glomerular filtration rate (GFR), which ultimately leads to ESRD. Objectives: Our study aimed to evaluate the relation between high-sensitivity C-reactive protein (hsCRP) and microalbuminuria in insulin dependent DM in children for early detection of diabetic nephropathy in these patients. Methods: Fifty diabetic patients with normoalbuminuria and 50 with microalbuminuria were included in the study. Patients with primary renal disease, cardiovascular disease, infections and those receiving NSAID or gentamycin were excluded from the study. Patients were subjected to complete urine analysis, albumin/' creatinine ratio, complete blood picture, renal function tests (blood urea nitrogen and serum creatinine), HbAIC, lipid profile (serum cholesterol, HDL, LDL and serum triglycerides), high sensitivity CRP using assay. Results: A significantly higher hsCRP was found in the microalbuminuric group than the normoalbuminuric group with significant positive correlations between microalbuminuria and hsCRP, НЬАlc, and duration of diabetes. Conclusions: high level of hsCRP in microalbuminuric patients is an early indicator of glornerular damage. Children and adolescents with IDDM should undergo annual monitoring for microalbuminuria and hsCRP, markers for identifying an individual at risk of diabetic nephropathy.