This article is dedicated to the surgeon A. A. Keeter (1813 -1879). He was one of the prominent students of N. I. Pirogov. He made a significant contribution to the science and clinical medicine. A. A. Keeter popularized new surgical techniques in gynecology and was the head of the first gynecological clinic in Russia. This clinic was opened in 1842 in Saint Petersburg State Medical Surgical Academy. He published the first detailed manual “Gynecologic diseases guidelines” in 1858. Moreover A.A. Keeter was the first surgeon in Russia who performed vaginal hysterectomy with successful result. Keeter was an outstanding scientist and founder of Russian surgical school.

The combination of pregnancy and cancer is a challenge for the patient and a problematic clinical dilemma for the doctor. In this retrospective observational cohort study, we have tried to analyze our experience in the management of such patients.This review includes 41 patients with malignant neoplasms detected during pregnancy who received treatment at the Almazov National Medical Research Centre from 2015-2021.The majority of patients received treatment during pregnancy (n=26, 63.4%): chemotherapy -19 (46.3%) (in 2 cases in combination with surgery), surgical treatment -7 (17, 1%) patients. In most cases, delivery was at term (n=28, 68.3%). All children born at term were mature and had no growth restriction, regardless of whether the mothers received treatment during pregnancy or not.When detecting cancer during pregnancy, an immediate follow-up examination is required to assess the extent of the tumor and current fetal state. If pregnancy prolongation is requested, the treatment should not be postponed, except for systemic chemotherapy in the first trimester of pregnancy, pelvic radiation at any term.